PMID- 11018504
OWN - NLM
STAT- MEDLINE
DCOM- 20001214
LR  - 20190921
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 111
IP  - 10
DP  - 2000 Oct
TI  - Modification of the silent period by double transcranial magnetic stimulation.
PG  - 1868-72
AB  - OBJECTIVES: To study the time course of the changes of the inhibitory network of 
      the human motor system, we investigated the silent period (SP) in 7 healthy 
      subjects by double suprathreshold transcranial magnetic stimulation (TMS). 
      METHODS: SPs and motor evoked potentials (MEPs) were recorded from the 
      voluntarily activated right abductor digiti minimi muscle. Conditioning and test 
      stimuli were delivered with equal intensity, which was set to yield a baseline SP 
      duration of 130 ms by a single pulse, and with various interstimulus intervals 
      (ISIs). In addition, a control experiment with adjustment of the intensity of 
      single stimuli was performed. RESULTS: At ISIs of 20 and 30 ms the test pulse SP 
      duration was prolonged, without increasing the MEP amplitude. The SP duration 
      shortened at longer ISIs and showed a significant depression between ISIs of 
      60-110 ms. The shortened SP was accompanied by a diminished MEP. The control 
      experiment revealed that the SPs evoked by the adjusted pulses were significantly 
      shorter than the test pulse SPs. CONCLUSIONS: A conditioning stimulus can prolong 
      and shorten the test pulse SP duration at different ISIs. The prolongation is 
      probably cortically generated, whereas the shortening is likely to occur at a 
      cortical and spinal level.
FAU - Wu, T
AU  - Wu T
AD  - Department of Clinical Neurophysiology, Georg August University, 
      Robert-Koch-Street 40, D-37075, Gottingen, Germany.
FAU - Sommer, M
AU  - Sommer M
FAU - Tergau, F
AU  - Tergau F
FAU - Paulus, W
AU  - Paulus W
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Electromyography
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Time Factors
MH  - *Transcranial Magnetic Stimulation
EDAT- 2000/10/06 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/06 11:00
PHST- 2000/10/06 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/06 11:00 [entrez]
AID - S1388-2457(00)00426-0 [pii]
AID - 10.1016/s1388-2457(00)00426-0 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2000 Oct;111(10):1868-72. doi: 10.1016/s1388-2457(00)00426-0.