PMID- 11019489
OWN - NLM
STAT- MEDLINE
DCOM- 20001030
LR  - 20061115
IS  - 1343-1420 (Print)
IS  - 1343-1420 (Linking)
VI  - 47
IP  - 3-4
DP  - 2000 Aug
TI  - Multiple endocrine neoplasia type 1: from bedside to benchside.
PG  - 108-17
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder 
      characterized by the combined occurrence of parathyroid, pancreatic endocrine, 
      and anterior pituitary tumors. MEN1 has two characteristics; a hormone excess and 
      a sometimes lethal outcome due to malignant tumors. The recent identification of 
      the MEN1 gene has opened the door to a much deeper understanding of this 
      syndrome. Germline MEN1 mutations have been identified in most MEN1 families. 
      They were not found, however, in families with familial pituitary tumors. Thus, 
      studies with the MEN1 gene helped to establish that mutation of some other 
      gene(s) is likely causative of the MEN1 phenocopy. These recent advances provide 
      for the identification of mutant MEN1 gene carriers who are at a high risk of 
      developing MEN1. The protein encoded by the MEN1 gene has been shown to function 
      in the regulation of JunD-activated transcription but much still remains to be 
      elucidated.
FAU - Yoshimoto, K
AU  - Yoshimoto K
AD  - Otsuka Department of Molecular Nutrition, University of Tokushima School of 
      Medicine, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - J Med Invest
JT  - The journal of medical investigation : JMI
JID - 9716841
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - *Multiple Endocrine Neoplasia Type 1/etiology/genetics/physiopathology
MH  - Mutation
MH  - Neoplasm Proteins/*genetics
MH  - *Pancreatic Neoplasms/etiology/genetics/physiopathology
MH  - *Parathyroid Neoplasms/etiology/genetics/physiopathology
MH  - *Pituitary Neoplasms/etiology/genetics/physiopathology
MH  - *Proto-Oncogene Proteins
RF  - 44
EDAT- 2000/10/06 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/06 11:00
PHST- 2000/10/06 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/06 11:00 [entrez]
PST - ppublish
SO  - J Med Invest. 2000 Aug;47(3-4):108-17.