PMID- 11020647
OWN - NLM
STAT- MEDLINE
DCOM- 20001128
LR  - 20190910
IS  - 0887-8994 (Print)
IS  - 0887-8994 (Linking)
VI  - 23
IP  - 2
DP  - 2000 Aug
TI  - Acute disseminated encephalomyelitis associated with poliomyelitis vaccine.
PG  - 177-9
AB  - A 6-year-old female patient with acute disseminated encephalomyelitis associated 
      with poliomyelitis vaccine virus is reported. She had a history of high fever, 
      headache, and gait disturbance. Neurologic examination confirmed spastic 
      triparesis, urinary incontinence, diminution of tactile sensation, and vision 
      deterioration. Hemography, serum laboratory findings, and urinalysis were normal. 
      The cerebrospinal fluid was clear, with normal pressure, 9 leukocytes/mm(3), and 
      27 mg/dL protein, but the myelin basic protein was elevated to 10.7 ng/mL. 
      T(2)-weighted magnetic resonance imaging disclosed multifocal high-intensity 
      lesions of the spinal cord. The serum polio virus type 2 antibody titer was 
      raised in the acute phase, and polio vaccine virus type 2 was detected in viral 
      cultures of the cerebrospinal fluid and pharynx swab and had undergone an A-G 
      neurovirulence mutation at nucleotide 481. Finally, she had human leukocyte 
      antigen (HLA)-Cw3 and HLA-DR2, to which multiple sclerosis is related in Japan. 
      Thus the cause of ADEM may have been related to her HLA type.
FAU - Ozawa, H
AU  - Ozawa H
AD  - Department of Pediatrics, Tokyo Metropolitan Hachioji Children's Hospital, 
      Hachioji, Tokyo, Japan.
FAU - Noma, S
AU  - Noma S
FAU - Yoshida, Y
AU  - Yoshida Y
FAU - Sekine, H
AU  - Sekine H
FAU - Hashimoto, T
AU  - Hashimoto T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Neurol
JT  - Pediatric neurology
JID - 8508183
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (Poliovirus Vaccine, Oral)
SB  - IM
CIN - Pediatr Neurol. 2001 Apr;24(4):325. PMID: 11419405
MH  - Child
MH  - Encephalomyelitis, Acute Disseminated/blood/diagnosis/*virology
MH  - Female
MH  - HLA-DR2 Antigen/blood
MH  - Humans
MH  - Poliovirus/*immunology
MH  - Poliovirus Vaccine, Oral/*adverse effects/cerebrospinal fluid
EDAT- 2000/10/06 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/06 11:00
PHST- 2000/10/06 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/06 11:00 [entrez]
AID - S0887-8994(00)00167-3 [pii]
AID - 10.1016/s0887-8994(00)00167-3 [doi]
PST - ppublish
SO  - Pediatr Neurol. 2000 Aug;23(2):177-9. doi: 10.1016/s0887-8994(00)00167-3.