PMID- 11022839
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20190831
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 15
IP  - 8
DP  - 2000 Aug
TI  - Hepatitis G virus genotypes in Australia, Papua New Guinea and the Solomon 
      Islands: a possible new Pacific type identified.
PG  - 952-6
AB  - BACKGROUND: Hepatitis G Virus (HGV)/GB Virus-C (GBV-C) is a newly discovered RNA 
      virus. Nucleotide sequence comparison and phylogenetic studies of the 5' 
      untranslated region (5'UTR) within the viral genome have identified at least 
      three different types which have provisionally been classified as type 1 (West 
      African origin), type 2 (North American origin) and type 3 (Asian origin). 
      METHODS AND RESULTS: The products of RT-PCR were sequenced by using blood donors 
      and patients infected with HGV/GBV-C in Australia, Papua New Guinea and the 
      Solomon Islands to investigate the genotype distribution in this area of the 
      world. All the Australian isolates showed strong sequence homology with type 2, 
      while the Papua New Guinea and Solomon Islands sequences were more closely 
      related, but differ from type 3, which has previously been reported from isolates 
      studied within Asia. CONCLUSIONS: Phylogenetic analysis suggests that these 
      latter sequences are either a new HGV/GBV-C Pacific type or a subtype of the 
      Asian type RNA virus. Isolates homologous with type 1 were not identified in 
      these population groups.
FAU - Mison, L
AU  - Mison L
AD  - Australian Red Cross Blood Service, Queensland, Brisbane. 
      lmison@arcbs.redcross.org.au
FAU - Hyland, C
AU  - Hyland C
FAU - Poidinger, M
AU  - Poidinger M
FAU - Borthwick, I
AU  - Borthwick I
FAU - Faoagali, J
AU  - Faoagali J
FAU - Aeno, U
AU  - Aeno U
FAU - Gowans, E
AU  - Gowans E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Australia/epidemiology
MH  - Flaviviridae/*genetics
MH  - Genetic Variation
MH  - Genome, Viral
MH  - Genotype
MH  - Hepatitis, Viral, Human/*genetics
MH  - Humans
MH  - Melanesia/epidemiology
MH  - Papua New Guinea/epidemiology
MH  - Phylogeny
MH  - RNA, Viral/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
MH  - Sequence Analysis, RNA
EDAT- 2000/10/07 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/10/07 11:00
PHST- 2000/10/07 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/10/07 11:00 [entrez]
AID - 10.1046/j.1440-1746.2000.02225.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2000 Aug;15(8):952-6. doi: 
      10.1046/j.1440-1746.2000.02225.x.