PMID- 11023813
OWN - NLM
STAT- MEDLINE
DCOM- 20010125
LR  - 20210409
IS  - 0264-6021 (Print)
IS  - 1470-8728 (Electronic)
IS  - 0264-6021 (Linking)
VI  - 351 Pt 2
IP  - Pt 2
DP  - 2000 Oct 15
TI  - Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by 
      protein interactions.
PG  - 289-305
AB  - The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK 
      (extracellular-signal-regulated kinase) pathway is at the heart of signalling 
      networks that govern proliferation, differentiation and cell survival. Although 
      the basic regulatory steps have been elucidated, many features of this pathway 
      are only beginning to emerge. This review focuses on the role of protein-protein 
      interactions in the regulation of this pathway, and how they contribute to 
      co-ordinate activation steps, subcellular redistribution, substrate 
      phosphorylation and cross-talk with other signalling pathways.
FAU - Kolch, W
AU  - Kolch W
AD  - The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube 
      Estate, Switchback Road, Bearsden, Glasgow G61 1BD, U.K. wkolch@beatson.gla.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-raf)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - Cell Membrane/metabolism
MH  - Cytosol/metabolism
MH  - Enzyme Activation
MH  - Mitogen-Activated Protein Kinase Kinases/*metabolism
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - Models, Biological
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Protein Binding
MH  - Proto-Oncogene Proteins c-raf/*metabolism
MH  - Sequence Homology, Amino Acid
MH  - *Signal Transduction
MH  - ras Proteins/*metabolism
PMC - PMC1221363
EDAT- 2000/10/12 11:00
MHDA- 2001/02/28 10:01
PMCR- 2001/04/15
CRDT- 2000/10/12 11:00
PHST- 2000/10/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/12 11:00 [entrez]
PHST- 2001/04/15 00:00 [pmc-release]
PST - ppublish
SO  - Biochem J. 2000 Oct 15;351 Pt 2(Pt 2):289-305.