PMID- 11025262
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20191104
IS  - 0958-3947 (Print)
IS  - 1873-4022 (Linking)
VI  - 25
IP  - 3
DP  - 2000 Fall
TI  - Modern prostate brachytherapy.
PG  - 149-53
AB  - As computer-aided margin tools become more sophisticated, physicists will be 
      increasingly called upon to convert ultrasound prostate volumes to expanded 
      planning target volumes (PTVs) to treat adequately extracapsular disease. The 
      American Association of Physicists in Medicine Task Group 43 formalism and the 
      new National Institute of Standards and Technology calibration system suitable 
      for single low-energy seeds have been crucial in smoothly implementing changes in 
      established seeds and in incorporating data from new manufacturers. However, the 
      lack of consensus on treatment design and evaluation has led to an uncomfortably 
      wide spectrum of clinical practice, only part of which can be attributed to 
      variations inherent to any surgical procedure due to the practitioner's skill. 
      The relative merits of implanting the prostate and margin with a modified uniform 
      seed-loading approach to create plans with a relatively homogeneous dose 
      distribution and a corresponding low risk of overdosing critical structures are 
      addressed. Likewise, the advantages of performing postoperative dosimetry at the 
      physically optimum time of greater than 2 weeks post implant are contrasted with 
      the clinical advantages of obtaining the dosimetry as soon as possible. Proposed 
      lower limits for quality parameters such D90 and V100 are reviewed. Measures of 
      doses to the urethra, rectum, and neurovascular bundles are presented, along with 
      correlations between various dosimetric parameters and other patient specific 
      data with quality of life metrics involving urinary incontinence, rectal damage, 
      and sexual dysfunction.
FAU - Butler, W M
AU  - Butler WM
AD  - Schiffler Oncology Center, Wheeling Hospital, WV 26003-6300, USA. 
      oncology@hgo.net
FAU - Merrick, G S
AU  - Merrick GS
FAU - Dorsey, A T
AU  - Dorsey AT
FAU - Lief, J H
AU  - Lief JH
FAU - Galbreath, R W
AU  - Galbreath RW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Dosim
JT  - Medical dosimetry : official journal of the American Association of Medical 
      Dosimetrists
JID - 8908862
SB  - IM
MH  - *Brachytherapy
MH  - Humans
MH  - Male
MH  - Prostatic Neoplasms/diagnostic imaging/*radiotherapy/surgery
MH  - Radiotherapy Dosage
MH  - Ultrasonography
EDAT- 2000/10/12 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/10/12 11:00
PHST- 2000/10/12 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/10/12 11:00 [entrez]
AID - S0958-3947(00)00041-8 [pii]
AID - 10.1016/s0958-3947(00)00041-8 [doi]
PST - ppublish
SO  - Med Dosim. 2000 Fall;25(3):149-53. doi: 10.1016/s0958-3947(00)00041-8.