PMID- 11026506
OWN - NLM
STAT- MEDLINE
DCOM- 20010201
LR  - 20061115
IS  - 0939-4451 (Print)
IS  - 0939-4451 (Linking)
VI  - 19
IP  - 1
DP  - 2000
TI  - Neurotrophic factors influence upregulation of constitutive isoform of heme 
      oxygenase and cellular stress response in the spinal cord following trauma. An 
      experimental study using immunohistochemistry in the rat.
PG  - 351-61
AB  - The influence of brain derived neurotrophic factor (BDNF) or insulin like growth 
      factor-1 (IGF-1) on spinal cord trauma induced carbon monoxide (CO) production 
      and cellular stress response was examined using immunostaining of the 
      constitutive isoform of the hemeoxygenase (HO-2) enzyme and the heat shock 
      protein (HSP 72kD) expression in a rat model. Subjection of rats to a 5 h spinal 
      trauma inflicted by an incision into the right dorsal horn at T10-11 segment 
      markedly upregulated the HO-2 and HSP expression in the adjacent spinal cord 
      segments (T9 and T12). Pretreatment with BDNF or IGF-1 significantly attenuated 
      the trauma induced HSP expression. The upregulation of HO-2 was also considerably 
      reduced. These results show that BDNF and IGF-1 attenuate cellular stress 
      response and production of CO following spinal cord injury which seems to be the 
      key factors in neurotrophins induced neuroprotection.
FAU - Sharma, H S
AU  - Sharma HS
AD  - Department of Medical Cell Biology, Biomedical Centre, Uppsala University, 
      Sweden. Sharma@medcellbiol.uu.se
FAU - Nyberg, F
AU  - Nyberg F
FAU - Gordh, T
AU  - Gordh T
FAU - Alm, P
AU  - Alm P
FAU - Westman, J
AU  - Westman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Immunohistochemistry
MH  - Male
MH  - Oxidative Stress
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/*enzymology/*pathology
MH  - Up-Regulation
EDAT- 2000/10/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/12 11:00
PHST- 2000/10/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/12 11:00 [entrez]
PST - ppublish
SO  - Amino Acids. 2000;19(1):351-61.