PMID- 11027976
OWN - NLM
STAT- MEDLINE
DCOM- 20001207
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 470
IP  - 2
DP  - 2000 Oct 31
TI  - Comparison of micronuclei frequencies in mono-, bi- and poly-nucleated 
      lymphocytes from subjects of a residential suburb and subjects living near a 
      metallurgical plant.
PG  - 211-9
AB  - Spontaneous baseline frequencies of micronuclei in mono-, bi- and poly-nucleated 
      lymphocytes were analyzed, using the cytokinesis-block technique, in 103 subjects 
      living in a residential suburb (Genova-Nervi), and in 203 subjects living in an 
      urban industrialized area near a metallurgical plant and a coke factory 
      (Genova-Cornigliano). Statistical analysis showed that the average frequency of 
      micronucleated binucleated lymphocytes (MnBNL) was significantly higher 
      (1.42-fold) in donors of Nervi than in donors of Cornigliano living in a 
      contaminated environment. In contrast, the average frequency of micronucleated 
      polynucleated lymphocytes (MnPNL) was significantly higher (1.66-fold) in donors 
      of Cornigliano than in donors of Nervi. The existence in the whole population 
      examined of a positive correlation between frequency of MnBNL and frequency of 
      MnPNL and the absence of a positive correlation between frequency of bi- and 
      poly-nucleated lymphocytes and frequency of MnPNL suggest that the formation of 
      MnPNL is a consequence of genetic damage and not of mitotic errors arising during 
      the division of bi- and poly-nucleated cells. In agreement with previous findings 
      the frequency of MnBNL increased with age and was significantly higher in females 
      than in males; unexpectedly it was higher in non-smokers/non-drinkers than in 
      smokers/drinkers.
FAU - Martelli, A
AU  - Martelli A
AD  - Department of Internal Medicine, Division of Clinical Pharmacology and 
      Toxicology, University of Genoa, Viale Benedetto XV 2, I-16132, Genoa, Italy.
FAU - Robbiano, L
AU  - Robbiano L
FAU - Cosso, M
AU  - Cosso M
FAU - Perrone, C
AU  - Perrone C
FAU - Tagliazucchi, A
AU  - Tagliazucchi A
FAU - Giuliano, L
AU  - Giuliano L
FAU - Aresca, G F
AU  - Aresca GF
FAU - Brambilla, G
AU  - Brambilla G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
SB  - IM
MH  - *Environmental Exposure
MH  - Female
MH  - Humans
MH  - Italy
MH  - Lymphocytes/*ultrastructure
MH  - Male
MH  - *Micronuclei, Chromosome-Defective
EDAT- 2000/10/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/12 11:00
PHST- 2000/10/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/12 11:00 [entrez]
AID - S138357180000108X [pii]
AID - 10.1016/s1383-5718(00)00108-x [doi]
PST - ppublish
SO  - Mutat Res. 2000 Oct 31;470(2):211-9. doi: 10.1016/s1383-5718(00)00108-x.