PMID- 11030523
OWN - NLM
STAT- MEDLINE
DCOM- 20010315
LR  - 20191104
IS  - 1076-0296 (Print)
IS  - 1076-0296 (Linking)
VI  - 6
IP  - 4
DP  - 2000 Oct
TI  - Differential effects of unfractionated heparin and low-molecular-weight heparins 
      on tissue thromboplastin inhibition test.
PG  - 190-6
AB  - Circulating anticoagulants are endogenously produced substances that interfere 
      with in vitro tests of coagulation like activated partial thromboplastin time 
      (APTT), and cause prolongation of the clotting times. Evaluation of the abnormal 
      APTT involving various factor assays and mixing studies may provide inconclusive 
      and ambiguous results. Tissue thromboplastin inhibition test (TTIT) is one of the 
      screening assays for detection of circulating anticoagulants. However, this test 
      is influenced by the presence of unfractionated heparin (UFH) from concentrations 
      0.2 U/mL and higher. Since low-molecular-weight heparins (LMWHs) are increasingly 
      used for the prevention of thrombotic disorders and may replace UFH in the 
      future, in this study the authors studied the influence of LMWHs on the 
      performance of TTIT and compared the results with UFH. UFH and LMWHs showed a 
      prolongation of TTIT in the concentration range of 0.25-1.0 U/mL. The marked 
      prolongation of the TTIT with UFH and different LMWHs is in decreasing order of 
      UFH > ardeparin > tinzaparin > dalteparin > enoxaparin. Patients with circulating 
      anticoagulants who are given LMWHs may have false-positive results of TTIT and 
      this influence should be kept in mind during patient management.
FAU - Gerbutavicius, R
AU  - Gerbutavicius R
AD  - Department of Hematology, Kaunas Medical University, Lithuania.
FAU - Iqbal, O
AU  - Iqbal O
FAU - Messmore, H
AU  - Messmore H
FAU - Hoppensteadt, D A
AU  - Hoppensteadt DA
FAU - Demir, M
AU  - Demir M
FAU - Khan, E
AU  - Khan E
FAU - Bacher, P
AU  - Bacher P
FAU - Fareed, J
AU  - Fareed J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
RN  - 9035-58-9 (Thromboplastin)
SB  - IM
MH  - Anticoagulants/blood/pharmacology
MH  - Blood Coagulation Tests/methods/standards
MH  - Dose-Response Relationship, Drug
MH  - False Positive Reactions
MH  - Heparin/blood/*pharmacology
MH  - Heparin, Low-Molecular-Weight/blood/pharmacology
MH  - Humans
MH  - Thromboplastin/*antagonists & inhibitors/drug effects
EDAT- 2000/10/13 11:00
MHDA- 2001/03/17 10:01
CRDT- 2000/10/13 11:00
PHST- 2000/10/13 11:00 [pubmed]
PHST- 2001/03/17 10:01 [medline]
PHST- 2000/10/13 11:00 [entrez]
AID - 10.1177/107602960000600402 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2000 Oct;6(4):190-6. doi: 10.1177/107602960000600402.