PMID- 11031345
OWN - NLM
STAT- MEDLINE
DCOM- 20001109
LR  - 20190723
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 106
IP  - 4
DP  - 2000 Oct
TI  - Modulation of the atopy patch test reaction by topical corticosteroids and tar.
PG  - 737-43
AB  - BACKGROUND: Pharmacologic studies in atopic eczema (AE) are difficult to 
      standardize. Patients with AE differ in the stage of their skin disease (acute, 
      subacute, chronic). OBJECTIVE: This study was designed to assess macroscopic and 
      microscopic effects of pretreatment with topical glucocortico-steroids (GCSs) and 
      tar on the atopy patch test (APT) reaction in patients with atopic eczema. 
      METHODS: Nonlesional skin of the back of patients with AE (n = 6) was treated for 
      3 weeks at 3 different sites with triamcin-olonacetonide 0.1% in cetamacrogol 
      ointment (GCSs), pix liquida 10% in cetamacrogol ointment (tar), and cetamacrogol 
      ointment (vehicle), respectively. APTs were performed, and biopsy specimens were 
      taken from all these sites (time = 0 and 24 hours) for immunohistochemical 
      analysis. RESULTS: Treatment with both GCSs and tar was able to reduce the 
      macroscopic outcome of the APT reaction. Furthermore, both treatment modalities 
      had an almost equally inhibiting effect on the influx of T cells, eosinophils, 
      and CD1(+), RFD1(+), IFN-gamma(+), and IL-4(+) cells, as well as on the 
      percentage of vessels expressing the adhesion molecules vascular cell adhesion 
      molecule 1 and E-selectin in response to epicutaneous aeroallergen challenge. 
      CONCLUSION: Although both treatments significantly reduced the various cellular 
      constituents of allergic inflammation, all cell types remained present. In 
      addition, this study shows that the APT can be used to evaluate the effect of 
      topical anti-inflammatory treatments on allergic inflammation in patients with 
      AE.
FAU - Langeveld-Wildschut, E G
AU  - Langeveld-Wildschut EG
AD  - Department of Dermatology/Allergology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Riedl, H
AU  - Riedl H
FAU - Thepen, T
AU  - Thepen T
FAU - Bihari, I C
AU  - Bihari IC
FAU - Bruijnzeel, P L
AU  - Bruijnzeel PL
FAU - Bruijnzeel-Koomen, C A
AU  - Bruijnzeel-Koomen CA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Glucocorticoids)
RN  - 0 (Ointments)
RN  - 0 (Tars)
RN  - F446C597KA (Triamcinolone Acetonide)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Dermatitis, Atopic/*diagnosis
MH  - Female
MH  - Glucocorticoids
MH  - Humans
MH  - Male
MH  - Ointments
MH  - Patch Tests/*methods
MH  - Skin/drug effects
MH  - Tars/*pharmacology
MH  - Time Factors
MH  - Triamcinolone Acetonide/administration & dosage
EDAT- 2000/10/14 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/14 11:00
PHST- 2000/10/14 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/14 11:00 [entrez]
AID - S0091674900781401 [pii]
AID - 10.1067/mai.2000.109831 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2000 Oct;106(4):737-43. doi: 10.1067/mai.2000.109831.