PMID- 11031826
OWN - NLM
STAT- MEDLINE
DCOM- 20001124
LR  - 20191210
IS  - 0300-9173 (Print)
IS  - 0300-9173 (Linking)
VI  - 37
IP  - 7
DP  - 2000 Jul
TI  - [Plasma cardiac natriuretic peptide as a biological marker of recurrence of 
      atrial fibrillation in elderly people].
PG  - 535-40
AB  - We designed this study to evaluate the relationship between plasma atrial 
      natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels and 
      recurrence of atrial fibrillation (AF) after direct current cardioversion (DC) 
      and the differences with aging. Fifty patients with mild congestive heart failure 
      (CHF) undergoing elective DC of AF were included in this study (New York Heart 
      Association (NYHA) functional class II: n = 42, III = 8). Patients who failed to 
      show restoration of sinus rhythm or those with mitral valve stenosis were 
      excluded. Before successful DC, we measured plasma levels of ANP and BNP and 
      evaluated left atrial dimension (LAD), left ventricular end-diastolic dimension 
      (LVDd), and left ventricular ejection fraction (EF) by echocardiography. 
      Twenty-one patients had recurrence of AF within 2 months after DC (average 9.05 
      days). We followed up the other 29 patients for 580.5 days. By Cox stepwise 
      multivariate analysis, history of AF (p = 0.007), low plasma levels of ANP (p = 
      0.003), and high plasma levels of BNP (p = 0.0003) were found to be independent 
      predictors of recurrent AF. High plasma BNP levels indicating ventricular 
      dysfunction and low plasma ANP levels may be due to atrial histological change 
      such as fibrosis. In these patients, plasma ratios of ANP and BNP (ANP/BNP) less 
      than 0.43 were predictive factors for AF recurrence (sensitivity 70%, specificity 
      62%), especially in patients who were older than 70 years (sensitivity 100%, 
      specificity 80%). Relatively low plasma ANP level compared to BNP is an 
      independent risk factor of AF recurrence in patients with CHF, especially in 
      elderly patients, suggesting that plasma cardiac natriuretic peptides are 
      important biochemical markers of AF recurrence in elderly patients with CHF.
FAU - Mabuchi, N
AU  - Mabuchi N
AD  - First Department of Internal Medicine, Shiga University of Medical Science.
FAU - Tsutamoto, T
AU  - Tsutamoto T
FAU - Maeda, K
AU  - Maeda K
FAU - Masahiko, K
AU  - Masahiko K
LA  - jpn
PT  - Evaluation Study
PT  - Journal Article
PL  - Japan
TA  - Nihon Ronen Igakkai Zasshi
JT  - Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
JID - 7507332
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*blood
MH  - Atrial Natriuretic Factor/*blood
MH  - Biomarkers/*blood
MH  - Female
MH  - Heart Failure/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Recurrence
MH  - Sensitivity and Specificity
EDAT- 2000/10/14 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/14 11:00
PHST- 2000/10/14 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/14 11:00 [entrez]
AID - 10.3143/geriatrics.37.535 [doi]
PST - ppublish
SO  - Nihon Ronen Igakkai Zasshi. 2000 Jul;37(7):535-40. doi: 
      10.3143/geriatrics.37.535.