PMID- 11032392
OWN - NLM
STAT- MEDLINE
DCOM- 20010201
LR  - 20191104
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 5
IP  - 5
DP  - 2000 Sep
TI  - Brain derived neurotrophic factor (BDNF) gene variants association with age at 
      onset and therapeutic response in schizophrenia.
PG  - 558-62
AB  - Schizophrenia is a heterogeneous disease involving genetic and environmental 
      factors. The frequency of structural brain abnormalities or physical anomalies 
      supports a neurodevelopmental etiology, especially in early onset schizophrenia. 
      Brain-Derived-Neurotrophic-Factor (BDNF) is involved in the neurodevelopment of 
      dopaminergic (DA)-related systems and interacts with the meso-limbic DA systems, 
      involved in the therapeutic response to antipsychotic drugs and substance abuse. 
      In addition, BDNF promotes and maintains dopamine D3 receptor (DRD3) expression. 
      In a French Caucasian population, we found no statistical difference in allele or 
      genotype distribution of the BDNF gene dinucleotide repeat polymorphism (166-174 
      bp) between the whole group of schizophrenic patients and controls. By contrast, 
      an excess of the 172-176 bp alleles was found in patients with late onset, in 
      neuroleptic-responding patients and in non-substance-abusing patients. BDNF gene 
      variants thus appear to be associated with developmental features of 
      schizophrenia. In addition, this association with good treatment responding was 
      independent from the association found with the DRD3 Ball gene polymorphism in 
      the same population. These results suggest an independent contribution of each 
      gene to a treatment-sensitive form of schizophrenia.
FAU - Krebs, M O
AU  - Krebs MO
AD  - Biological Psychiatry Laboratory UPRES EA 2501, University of Paris V, 
      Sainte-Anne Hospital, France. krebs@chsa.broca.inserm.fr
FAU - Guillin, O
AU  - Guillin O
FAU - Bourdell, M C
AU  - Bourdell MC
FAU - Schwartz, J C
AU  - Schwartz JC
FAU - Olie, J P
AU  - Olie JP
FAU - Poirier, M F
AU  - Poirier MF
FAU - Sokoloff, P
AU  - Sokoloff P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Antipsychotic Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Polymorphism, Genetic
MH  - Schizophrenia/*drug therapy/*genetics
EDAT- 2000/10/14 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/14 11:00
PHST- 2000/10/14 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/14 11:00 [entrez]
AID - 10.1038/sj.mp.4000749 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2000 Sep;5(5):558-62. doi: 10.1038/sj.mp.4000749.