PMID- 11035207
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20190818
IS  - 0196-9781 (Print)
IS  - 0196-9781 (Linking)
VI  - 21
IP  - 8
DP  - 2000 Aug
TI  - Opposing interplay between Neuropeptide FF and nitric oxide in antinociception 
      and hypothermia.
PG  - 1209-13
AB  - This study examined the ability of the anti-opioid Neuropeptide FF (NPFF) to 
      modify the endogenous activity of nitric oxide (NO). Antinociceptive and 
      hypothermic effects of 1DMe (D.Tyr-Leu-(n.Me)Phe-Gln-Pro-Gln-Arg-Phe-NH(2)), an 
      NPFF agonist, and of L-NAME (N(omega)nitro-L-arginine methyl ester), an inhibitor 
      of nitric oxide synthase, were investigated in mice. Intraperitoneal (i.p.) 
      injection of L-NAME induced, in the hot plate test, a dose-dependent 
      antinociception not reversed by naloxone, an opioid antagonist, but inhibited by 
      L-Arg, the NO synthesis precursor. Intracerebroventricular (i.c.v.) injections of 
      1DMe inhibit the antinociceptive activity of L-NAME in a dose-dependent manner. 
      On the contrary, L-NAME markedly potentiated hypothermia induced by 1DMe injected 
      in the third ventricle. These data show that Neuropeptide FF receptors exert a 
      dual effect on endogenous NO functions and could modulate pain transmission 
      independently of opioids.
FAU - Zajac, J M
AU  - Zajac JM
AD  - Institut de Pharmacologie et Biologie Structurale, CNRS 205 route de Narbonne 
      31077 cedex, Toulouse, France.
FAU - Latapie, J P
AU  - Latapie JP
FAU - Frances, B
AU  - Frances B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Oligopeptides)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 36B82AMQ7N (Naloxone)
RN  - 76I7G6D29C (Morphine)
RN  - 94ZLA3W45F (Arginine)
RN  - 99566-27-5 
      (phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Analgesics, Opioid/pharmacology
MH  - Animals
MH  - Area Under Curve
MH  - Arginine/pharmacology
MH  - Body Temperature
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/pharmacology
MH  - Free Radical Scavengers/metabolism
MH  - Hypothermia/*metabolism
MH  - Male
MH  - Mice
MH  - Morphine/pharmacology
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Naloxone/pharmacology
MH  - Narcotic Antagonists/*metabolism/pharmacology
MH  - Nitric Oxide/*metabolism
MH  - Oligopeptides/*metabolism
MH  - Pain/*drug therapy
MH  - Temperature
EDAT- 2000/10/18 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/18 11:00
PHST- 2000/10/18 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/18 11:00 [entrez]
AID - S0196-9781(00)00261-8 [pii]
AID - 10.1016/s0196-9781(00)00261-8 [doi]
PST - ppublish
SO  - Peptides. 2000 Aug;21(8):1209-13. doi: 10.1016/s0196-9781(00)00261-8.