PMID- 11035824
OWN - NLM
STAT- MEDLINE
DCOM- 20001128
LR  - 20211001
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 137
IP  - 4
DP  - 2000 Oct
TI  - The association of atopic dermatitis in infancy with immunoglobulin E food 
      sensitization.
PG  - 475-9
AB  - OBJECTIVE: To prospectively investigate the association of high levels of 
      immunoglobulin E (IgE) sensitization to foods and the presence of atopic 
      dermatitis (judged by reported topical steroid use during the first 16 months of 
      life) in a birth cohort of 620 Australian children "at risk" of allergic disease 
      because of family history. RESULTS: A total of 559 of the children in the cohort 
      were fully evaluated, and the cumulative prevalence of atopic dermatitis was 24%. 
      More children in the cohort who had atopic dermatitis had strongly positive skin 
      test results (> or = 4+, histamine equivalent units, > or = approximately 6-mm 
      wheal), consistent with IgE food sensitization to either cow's milk, egg, or 
      peanut at 6 months (22% vs 5%, chi(2) = 35; P < 10(-6)) and at 12 months (36% vs 
      11%, chi(2) = 41; P < 10(-6)) than those without atopic dermatitis. The 
      calculated attributable risk percent for IgE food sensitization as a cause of 
      atopic dermatitis was 65% and 64% at these times. In a separate group of infants 
      with severe atopic dermatitis, the equivalent rates of IgE food sensitization at 
      6 months was 83% and at 12 months, 65%. CONCLUSION: IgE food sensitization is a 
      major risk factor for the presence of atopic dermatitis in infancy.
FAU - Hill, D J
AU  - Hill DJ
AD  - Department of Allergy, Royal Children's Hospital, Melbourne, Victoria, Australia.
FAU - Sporik, R
AU  - Sporik R
FAU - Thorburn, J
AU  - Thorburn J
FAU - Hosking, C S
AU  - Hosking CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Dermatitis, Atopic/*complications/immunology
MH  - Food Hypersensitivity/*complications/immunology
MH  - Humans
MH  - *Immunoglobulin E/immunology
MH  - Infant
MH  - Prospective Studies
MH  - Severity of Illness Index
EDAT- 2000/10/18 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/18 11:00
PHST- 2000/10/18 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/18 11:00 [entrez]
AID - S0022-3476(00)07612-5 [pii]
AID - 10.1067/mpd.2000.108207 [doi]
PST - ppublish
SO  - J Pediatr. 2000 Oct;137(4):475-9. doi: 10.1067/mpd.2000.108207.