PMID- 11038763
OWN - NLM
STAT- MEDLINE
DCOM- 20001213
LR  - 20061115
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 19
IP  - 4
DP  - 1997 Jul
TI  - [Serum tumor necrosis factor-alpha levels in non-Hodgkin's lymphoma patients and 
      its relationship to prognosis].
PG  - 293-6
AB  - OBJECTIVE: To explore the relationship of tumor necrosis factor-alpha (TNF alpha) 
      with non-Hodgkin's lymphoma (NHL) and to evaluate clinical implication of serum 
      TNF alpha. METHODS: Serum TNF alpha levals were measured by double-antibody 
      sandwich enzyme-linked immunosorbent assay (ELISA) in 76 NHL patients. Survival 
      analysis was performed. RESULTS: Serum TNF alpha was increased in 55% newly 
      diagnosed patients, and dropped to normal level on remission but increased again 
      on relapse. Elevated TNF alpha levels of patients at diagnosis were significantly 
      associated with Ann Arbor stage, bulky tumor and B symptoms, but weren't 
      correlated to serum lactic-dehydrogenase (LDH) nor to beta 2-microglobulin (beta 
      2-MG). The survival period of patients with elevated TNF alpha levels was shorter 
      than that of patients with normal TNF alpha levels. CONCLUSION: Elevated serum 
      TNF alpha level is associated with high tumor burden and can be used as a 
      prognostic marker.
FAU - Li, D
AU  - Li D
AD  - Department of Hematology, Affiliated Hospital of Weifang Medical College.
FAU - Li, G
AU  - Li G
FAU - Wang, B
AU  - Wang B
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
RN  - 0 (Interleukin-2)
RN  - 0 (Receptors, Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Interleukin-2/blood
MH  - Lymphoma, Non-Hodgkin/*blood/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Receptors, Interleukin-6/blood
MH  - Survival Rate
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1997/07/01 00:00
MHDA- 2001/02/28 10:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 1997 Jul;19(4):293-6.