PMID- 11038802
OWN - NLM
STAT- MEDLINE
DCOM- 20001206
LR  - 20061115
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 78
IP  - 8
DP  - 1998 Aug
TI  - [Brain cell apoptosis after cerebral hypoxia-ischemia in neonatal rat].
PG  - 567-9
AB  - OBJECTIVE: To investigate action of apoptosis in mechanisms of neonatal 
      hypoxia-ischemia (HIE). METHODS: Using HE staining, electronmicroscope, and 
      terminal deoxynuleotidyl transferase-mediated dUTP nick end labeling (TUNEL) 
      technique, we observed the histological features, time course and density of 
      apoptotic cells and compared the ipsilateral hemisphere after permanent ischemia 
      1, 4, 18, 24, 40, 72 h, 7 days after 3 h hypoxia with that of sham-group. 
      RESULTS: Neurons in the cortex, hippocampus, thalamus exhibited cells shrink, 
      chromatin condensation, apoptosis bodys under microscope, as demonstrated by in 
      situ labeling of DNA breaks. The peak for apoptosis was shown at 18 h in the 
      cortex. CONCLUSION: In the HIE, apoptosis appears earlier than necrosis, and both 
      of the different cell death forms may exist induced dose relativity.
FAU - Jiang, L
AU  - Jiang L
AD  - Department of Pediatrics, Nanjing Railway Medical College.
FAU - Tang, Y
AU  - Tang Y
FAU - Huang, X
AU  - Huang X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - *Apoptosis
MH  - Brain/*pathology
MH  - Hypoxia-Ischemia, Brain/*pathology
MH  - Necrosis
MH  - Neurons/pathology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2000/10/20 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/20 11:00
PHST- 2000/10/20 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/20 11:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 1998 Aug;78(8):567-9.