PMID- 11040222
OWN - NLM
STAT- MEDLINE
DCOM- 20001121
LR  - 20190722
IS  - 1524-4563 (Electronic)
IS  - 0194-911X (Linking)
VI  - 36
IP  - 4
DP  - 2000 Oct
TI  - Evidence for a gene influencing blood pressure on chromosome 17. Genome scan 
      linkage results for longitudinal blood pressure phenotypes in subjects from the 
      framingham heart study.
PG  - 477-83
AB  - Hypertension is a leading cause of morbidity and mortality. Efforts to identify 
      hypertension genes have focused on 3 approaches: mendelian disorders, candidate 
      genes, and genome-wide scans. Thus far, these efforts have not identified genes 
      that contribute substantively to overall blood pressure (BP) variation in the 
      community. A 10-centiMorgan (cM) density genome-wide scan was performed in the 
      largest families from 2 generations of Framingham Heart Study participants. 
      Heritability and linkage for long-term mean systolic and diastolic BP phenotypes 
      were analyzed by use of SOLAR software. Heritability estimates were based on BP 
      measurements in 1593 families. Genotyping was performed on 1702 subjects from 332 
      large families, and BP data were available for 1585 (93%) genotyped subjects who 
      contributed 12 588 longitudinal BP observations. The mean age was 47 years, and 
      mean BP was 127/80 (systolic/diastolic) mm Hg. Long-term systolic and diastolic 
      BP phenotypes had high heritability estimates, 0.57 and 0.56, respectively. For 
      systolic BP, multipoint log-of-the-odds (LOD) scores >2.0 were located on 
      chromosome 17 at 67 cM (LOD 4.7, P=0.0000016) and 94 cM (LOD 2.2). For diastolic 
      BP, LOD scores >2.0 were identified on chromosome 17 (74 cM, LOD 2.1) and 
      chromosome 18 (7 cM, LOD 2.1). Using a genome-wide scan, we found strong evidence 
      for a BP quantitative trait locus on chromosome 17. Follow-up studies are 
      warranted to identify the gene or genes in this quantitative trait locus that 
      influence BP. Such knowledge could extend our understanding of the genetic basis 
      of essential hypertension and have implications for the evaluation and treatment 
      of patients with high BP.
FAU - Levy, D
AU  - Levy D
AD  - National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, 
      Massachusetts, USA.
FAU - DeStefano, A L
AU  - DeStefano AL
FAU - Larson, M G
AU  - Larson MG
FAU - O'Donnell, C J
AU  - O'Donnell CJ
FAU - Lifton, R P
AU  - Lifton RP
FAU - Gavras, H
AU  - Gavras H
FAU - Cupples, L A
AU  - Cupples LA
FAU - Myers, R H
AU  - Myers RH
LA  - eng
GR  - N01-HC-38038/HC/NHLBI NIH HHS/United States
GR  - P50HL55001/HL/NHLBI NIH HHS/United States
GR  - P50HL55007/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
SB  - IM
CIN - Hypertension. 2000 Oct;36(4):469-70. PMID: 11040220
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure/*genetics
MH  - Body Height
MH  - Body Weight
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Cohort Studies
MH  - Diastole
MH  - Female
MH  - *Genes
MH  - Genetic Linkage/*genetics
MH  - Genotype
MH  - Humans
MH  - Lod Score
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Prospective Studies
MH  - Quantitative Trait, Heritable
MH  - Regression Analysis
MH  - Systole
EDAT- 2000/10/21 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/21 11:00
PHST- 2000/10/21 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/21 11:00 [entrez]
AID - 10.1161/01.hyp.36.4.477 [doi]
PST - ppublish
SO  - Hypertension. 2000 Oct;36(4):477-83. doi: 10.1161/01.hyp.36.4.477.