PMID- 1104348
OWN - NLM
STAT- MEDLINE
DCOM- 19760301
LR  - 20191028
IS  - 0093-6391 (Print)
IS  - 0093-6391 (Linking)
VI  - 2
IP  - 6-7
DP  - 1975
TI  - Post-coital contraceptive and uterotrophic effects of luteinizing hormone 
      releasing hormone.
PG  - 445-58
AB  - LRH, administered subcutaneously (s.c.) or orally (p.o.) to female rats, was 
      capable of interfering with pregnancy when given on various days of gestation. A 
      100% inhibition of pregnancy was demonstrated at daily s.c. doses of 1000 mug/rat 
      administered over days 1-7; LRH also was effective as an interceptive, 
      terminating pregnancy in 100% of rats when delivered from days 7-12 of pregnancy 
      at a daily dose of 1000 mug/rat s.c. or p.o. An 80% inhibition also was observed 
      in rabbits administered LRH from days 1-7 at a total dose of 1000 mug/kg, s.c. 
      Uterotrophic studies demonstrated that LRH, administered s.c. to intact immature 
      mice, produces a dose-related increase in uterine and ovarian weight and 
      initiates vaginal opening. The hypothalamic hormone also produced a dose-related 
      increase in uterine weight in ovariectomized mice and hypophysectomized rats. The 
      data suggest that LRH has a post-coital contraceptive effect, presumably acting 
      via hyperstimulation of the hypophysial-ovarian steroid-uterine axis, and/or by a 
      direct extrapituitary (uterine) effect.
FAU - Corbin, A
AU  - Corbin A
FAU - Beattie, C W
AU  - Beattie CW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocr Res Commun
JT  - Endocrine research communications
JID - 0426337
RN  - 0 (Contraceptives, Postcoital)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Castration
MH  - Contraceptives, Postcoital/*pharmacology
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*pharmacology
MH  - Hypophysectomy
MH  - Mice
MH  - Ovary/drug effects/*physiology
MH  - Pregnancy
MH  - Rabbits
MH  - Rats
MH  - Uterus/drug effects/*physiology
OID - PIP: 752414
OID - POP: 00023847
OAB - A study demonstrated that luteinizing hormone-releasing hormone (LRH ) when 
      administered subcutaneously (sc) or orally (po) to female rats can interfere with 
      pregnancy and that the hormone posseses extrapituitary activity. Pregnancy was 
      inhibited 100% when daily sc doses of 1000 mcg/rat were given from Days 1 to 7. 
      LRH effectively intercepted and terminated pregnancy in 100% of rats delivered 
      from Days 7 to 12 of pregnancy at a daily dose of 1000 mcg/rat sc or po. When 
      rabbits were administered LRH from Days 1 to 6 at a total dose of 1000 mcg/kg sc, 
      and 80% inhibition was noted. Uterotrophic studies revealed that LRH, when 
      administered sc to intact immature mice, produced a dose-related increase in 
      uterine and ovarian weight and initiates vaginal opening. A dose-related increase 
      in uterine weight as produced by the hypothalamic hormone was exhibited in 
      ovariectomized mice and hypophysectomized rats. Data demonstrate that LRH has an 
      extrapituitary and antipregnancy postcoital effect.
OABL- eng
OTO - PIP
OT  - *Animals, Laboratory
OT  - Biology
OT  - Clinical Research
OT  - Contraception
OT  - Contraceptive Agents
OT  - Contraceptive Agents, Female
OT  - *Contraceptive Agents, Postcoital
OT  - Endocrine System
OT  - Family Planning
OT  - *Fertility Control, Postconception
OT  - Genitalia
OT  - Genitalia, Female
OT  - Gonadotropins
OT  - Gonadotropins, Pituitary
OT  - Hormones
OT  - *Luteinizing Hormone
OT  - *Ovarian Effects
OT  - Ovary
OT  - Physiology
OT  - *Pituitary Hormone Releasing Hormones
OT  - Research Methodology
OT  - Urogenital System
OT  - *Uterine Effects
OT  - Uterus
EDAT- 1975/01/01 00:00
MHDA- 1975/01/01 00:01
CRDT- 1975/01/01 00:00
PHST- 1975/01/01 00:00 [pubmed]
PHST- 1975/01/01 00:01 [medline]
PHST- 1975/01/01 00:00 [entrez]
AID - 10.1080/07435807509084166 [doi]
PST - ppublish
SO  - Endocr Res Commun. 1975;2(6-7):445-58. doi: 10.1080/07435807509084166.