PMID- 11043515
OWN - NLM
STAT- MEDLINE
DCOM- 20001030
LR  - 20061115
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 45
IP  - 5
DP  - 2000
TI  - Genomic structure and chromosomal localization of the gene encoding TRAX, a 
      Translin-associated factor X.
PG  - 305-8
AB  - The TRAX gene encodes a Translin-associated 33-kDa protein partner, TRAX. The 
      TRAX protein has extensive amino acid homology with Translin, and contains 
      bipartite nuclear targeting sequences, suggesting a possible role in the 
      selective nuclear transport of Translin lacking any nuclear targeting motifs. In 
      the present study, genomic clones of the human TRAX gene were isolated to 
      determine the complete genomic organization. The genomic structure of the human 
      TRAX gene was similar to that of the human Translin gene, consisting of six exons 
      and five introns, encompassing approximately 27kb in genomic DNA. Northern blot 
      analysis revealed a predominant transcript of approximately 2.7kb, and its 
      distribution in various tissues was like that of Translin. Chromosomal mapping by 
      fluorescence in situ hybridization (FISH) analysis allowed localization of the 
      TRAX gene to human chromosome lq41.
FAU - Meng, G
AU  - Meng G
AD  - Department of Immunology, National Institute of Infectious Diseases, Tokyo, 
      Japan.
FAU - Aoki, K
AU  - Aoki K
FAU - Tokura, K
AU  - Tokura K
FAU - Nakahara, K
AU  - Nakahara K
FAU - Inazawa, J
AU  - Inazawa J
FAU - Kasai, M
AU  - Kasai M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (TSN protein, human)
RN  - 0 (TSNAX protein, human)
SB  - IM
MH  - Carrier Proteins/*genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - *DNA-Binding Proteins
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Nuclear Proteins/*genetics
EDAT- 2000/10/24 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/24 11:00
PHST- 2000/10/24 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/24 11:00 [entrez]
AID - 10.1007/s100380070022 [doi]
PST - ppublish
SO  - J Hum Genet. 2000;45(5):305-8. doi: 10.1007/s100380070022.