PMID- 11043811
OWN - NLM
STAT- MEDLINE
DCOM- 20010301
LR  - 20061115
IS  - 1323-1316 (Print)
IS  - 1323-1316 (Linking)
VI  - 54
IP  - 5
DP  - 2000 Oct
TI  - Presence of human herpesvirus 6 and herpes simplex virus detected by polymerase 
      chain reaction in surgical tissue from temporal lobe epileptic patients.
PG  - 589-93
AB  - We investigated the presence of human herpesvirus 6 (HHV-6) and herpes simplex 
      virus (HSV) in surgical tissue from temporal lobe epileptic patients. A total of 
      17 cases were studied, including eight males and nine females. The mean age was 
      24.9 +/- 11.1 years and the mean age of onset was 11.1 +/- 5.4 years. Five 
      patients were diagnosed as encephalitis/meningitis and another three had a 
      history of suspected encephalitis/meningitis, but no patient showed any obvious 
      neurological symptom or mental handicap. Mesial and lateral temporal tissues were 
      examined by polymerase chain reaction. Among six patients positive for HHV-6 
      (35%), the mesial temporal lobe was positive in four and the lateral temporal 
      lobe was positive in three. Herpes simplex virus was positive in only one 
      patient. Three of the six patients positive for HHV-6 did not show any apparent 
      causes. Mild encephalitis/meningitis induced by HHV-6, a condition sometimes not 
      recognized as encephalitis/meningitis, may be one of the most frequent causes of 
      temporal lobe epilepsy.
FAU - Uesugi, H
AU  - Uesugi H
AD  - Department of Psychiatry, National Center Hospital for Mental, Nervous, and 
      Muscular Disorders, Kodaira, Tokyo, Japan.
FAU - Shimizu, H
AU  - Shimizu H
FAU - Maehara, T
AU  - Maehara T
FAU - Arai, N
AU  - Arai N
FAU - Nakayama, H
AU  - Nakayama H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
SB  - IM
MH  - Adult
MH  - Culture Techniques
MH  - Encephalitis, Herpes Simplex/complications/diagnosis/*virology
MH  - Epilepsy, Temporal Lobe/etiology/*surgery
MH  - Female
MH  - Herpesviridae Infections/complications/diagnosis/*virology
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Male
MH  - *Polymerase Chain Reaction
MH  - Temporal Lobe/*surgery/*virology
EDAT- 2000/10/24 11:00
MHDA- 2001/03/07 10:01
CRDT- 2000/10/24 11:00
PHST- 2000/10/24 11:00 [pubmed]
PHST- 2001/03/07 10:01 [medline]
PHST- 2000/10/24 11:00 [entrez]
AID - 10.1046/j.1440-1819.2000.00758.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2000 Oct;54(5):589-93. doi: 
      10.1046/j.1440-1819.2000.00758.x.