PMID- 11043972
OWN - NLM
STAT- MEDLINE
DCOM- 20001129
LR  - 20161021
IS  - 1641-4640 (Print)
IS  - 1509-572X (Linking)
VI  - 38
IP  - 3
DP  - 2000
TI  - Major histocompatibility complex class II (MHC II) expression during the 
      development of human fetal cerebral occipital lobe, cerebellum, and hematopoietic 
      organs.
PG  - 111-8
AB  - In adults, under physiological conditions proteins of the major 
      histocompatibility complex, class II (MHC II) molecules are synthesized and then 
      presented on the surface of the cells known under a common name as antigen 
      presenting cells (APCs). Dendritic cells (DCs), microglia, macrophages, ameboid 
      microglia and lymphocytes B are qualified as APCs. The aim of present study was 
      to evaluate the expression of MHC II molecules in the central nervous system 
      (CNS) and hematopoietic organs during the fetal development. Observations were 
      made on the cerebral occipital lobe, cerebellum, thymus, spleen and liver of 30 
      normal human fetuses, between 11 and 22 week of gestation (GW). Histological, 
      histochemical and immunohistochemical techniques were used to identify cells with 
      expression of MHC II molecules. In the brain, MHC II molecules were detected on 
      macrophages/ameboid microglia in meninges, choroid plexus and single cells of 
      ramified microglia in deeper layers of the cortex and white matter. In the other 
      organs besides macrophages and dendritic cells, MHC II molecules were also 
      immunopositive in thymic epithelial cells, and in the spleen and liver also in 
      other cells of stroma and lobule. The expression of MHC II molecules on so 
      extensive population of cells, at an early stage of the fetal development, may 
      evidence their significant involvement in histogenesis and morphogenesis. It 
      seems that in adults the complex of MHC II with protein is originated from the 
      foreign antigen. On the contrary, during normal fetal development the complex of 
      MHC II with protein origins most probably from the fetus own structures.
FAU - Wierzba-Bobrowicz, T
AU  - Wierzba-Bobrowicz T
AD  - Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, 
      Poland. bobrow@ipin.edu.pl
FAU - Kosno-Kruszewska, E
AU  - Kosno-Kruszewska E
FAU - Gwiazda, E
AU  - Gwiazda E
FAU - Lechowicz, W
AU  - Lechowicz W
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Folia Neuropathol
JT  - Folia neuropathologica
JID - 9437431
SB  - IM
MH  - Adult
MH  - Cerebellum/*growth & development/ultrastructure
MH  - Embryonic and Fetal Development/*genetics
MH  - Genes, MHC Class II/*genetics
MH  - Hematopoietic System/*ultrastructure
MH  - Humans
MH  - Microglia/ultrastructure
MH  - Occipital Lobe/*growth & development/ultrastructure
EDAT- 2000/10/24 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/24 11:00
PHST- 2000/10/24 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/24 11:00 [entrez]
PST - ppublish
SO  - Folia Neuropathol. 2000;38(3):111-8.