PMID- 11044133
OWN - NLM
STAT- MEDLINE
DCOM- 20001121
LR  - 20190508
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 74
IP  - 22
DP  - 2000 Nov
TI  - Porcine reproductive and respiratory syndrome virus: description of persistence 
      in individual pigs upon experimental infection.
PG  - 10834-7
AB  - We studied the persistence of porcine reproductive and respiratory syndrome virus 
      (PRRSV) in individual experimentally infected pigs, during a period of up to 150 
      days postinfection (dpi). The results of this study suggest that the persistence 
      of PRRSV involves continuous viral replication but that it is not a true 
      steady-state persistent infection. The virus eventually clears the body and seems 
      to do it in most of the animals by 150 dpi or shortly thereafter. High genetic 
      stability was seen for several regions of the persistent PRRSV's genome, although 
      some consistent mutations in the genes of envelope glycoproteins and M protein 
      were also observed.
FAU - Allende, R
AU  - Allende R
AD  - Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, 
      Lincoln, Nebraska 68583-0905, USA.
FAU - Laegreid, W W
AU  - Laegreid WW
FAU - Kutish, G F
AU  - Kutish GF
FAU - Galeota, J A
AU  - Galeota JA
FAU - Wills, R W
AU  - Wills RW
FAU - Osorio, F A
AU  - Osorio FA
LA  - eng
SI  - GENBANK/AF299404
SI  - GENBANK/AF299405
SI  - GENBANK/AF299406
SI  - GENBANK/AF299407
SI  - GENBANK/AF299408
SI  - GENBANK/AF299409
SI  - GENBANK/AF299410
SI  - GENBANK/AF299411
SI  - GENBANK/AF299412
SI  - GENBANK/AF299413
SI  - GENBANK/AF299414
SI  - GENBANK/AF299415
SI  - GENBANK/AF299416
SI  - GENBANK/AF299417
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Amino Acid Substitution
MH  - Animals
MH  - Chronic Disease
MH  - Gene Expression
MH  - Molecular Sequence Data
MH  - Porcine Reproductive and Respiratory Syndrome/*virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/isolation & 
      purification/*physiology
MH  - Swine
MH  - Viral Proteins/genetics/metabolism
MH  - Virus Replication
PMC - PMC110963
EDAT- 2000/10/24 11:00
MHDA- 2001/02/28 10:01
PMCR- 2000/11/01
CRDT- 2000/10/24 11:00
PHST- 2000/10/24 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/24 11:00 [entrez]
PHST- 2000/11/01 00:00 [pmc-release]
AID - 0813 [pii]
AID - 10.1128/jvi.74.22.10834-10837.2000 [doi]
PST - ppublish
SO  - J Virol. 2000 Nov;74(22):10834-7. doi: 10.1128/jvi.74.22.10834-10837.2000.