PMID- 11045470
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20190706
IS  - 0009-2363 (Print)
IS  - 0009-2363 (Linking)
VI  - 48
IP  - 10
DP  - 2000 Oct
TI  - Enantioselective synthesis of the key intermediate of the acyl-CoA: cholesterol 
      acyltransferase (ACAT) inhibitor (R-106578) using 
      2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP)-Ru(OAc)2 as a catalyst.
PG  - 1567-9
AB  - Acidic segment of an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, 
      R-106578 was synthesized by enantioselective hydrogenation of the Z-olefine 
      (9-(Z)) using (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP)-Ru(OAc)2 as 
      a catalyst in methanol at 100 degrees C, 5 kgf/cm2 of H2 pressure. The requisite 
      Z-olefine was prepared regioselectively via coumarin derivative (5).
FAU - Murakami, M
AU  - Murakami M
AD  - Process Development Laboratories, Sankyo Co., Ltd., Kanagawa, Japan.
FAU - Kobayashi, K
AU  - Kobayashi K
FAU - Hirai, K
AU  - Hirai K
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Chem Pharm Bull (Tokyo)
JT  - Chemical & pharmaceutical bulletin
JID - 0377775
RN  - 0 (2,2'-bis(diphenylphosphino)-1,1'-binaphthyl-Ru(OAc)2)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Organometallic Compounds)
RN  - EC 2.3.1.26 (Sterol O-Acyltransferase)
SB  - IM
MH  - Catalysis
MH  - Enzyme Inhibitors/*chemical synthesis/chemistry
MH  - Organometallic Compounds/*chemical synthesis/chemistry
MH  - Stereoisomerism
MH  - Sterol O-Acyltransferase/*antagonists & inhibitors
EDAT- 2000/10/25 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/10/25 11:00
PHST- 2000/10/25 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/10/25 11:00 [entrez]
AID - 10.1248/cpb.48.1567 [doi]
PST - ppublish
SO  - Chem Pharm Bull (Tokyo). 2000 Oct;48(10):1567-9. doi: 10.1248/cpb.48.1567.