PMID- 11045567
OWN - NLM
STAT- MEDLINE
DCOM- 20001103
LR  - 20230216
IS  - 0023-6837 (Print)
IS  - 0023-6837 (Linking)
VI  - 80
IP  - 10
DP  - 2000 Oct
TI  - The imprinted gene Peg3 is not essential for tumor necrosis factor alpha 
      signaling.
PG  - 1509-11
AB  - The imprinted gene Peg3 encodes a zinc-finger protein which has been proposed to 
      be involved in tumor necrosis factor alpha (TNF) signaling via an interaction 
      with TNF receptor-associated factor 2 (TRAF2). Primary embryonic fibroblasts 
      derived from mice with a null mutation in Peg3 showed no abnormalities in 
      TNF-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) or 
      phosphorylation of the mitogen-activated protein kinases, extracellular 
      signal-regulated kinases 1 and 2, c-Jun N-terminal kinase/stress-activated 
      protein kinase (JNK/SAPK), and p38. In addition, the loss of Peg3 function did 
      not increase the sensitivity of the cells to the cytotoxic action of TNF. These 
      results suggest that Peg3 does not play an essential role in TNF signal 
      transduction.
FAU - Ledgerwood, E C
AU  - Ledgerwood EC
AD  - Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's 
      Hospital, United Kingdom. lizl@sanger.otago.ac.nz
FAU - O'Rahilly, S
AU  - O'Rahilly S
FAU - Surani, M A
AU  - Surani MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lab Invest
JT  - Laboratory investigation; a journal of technical methods and pathology
JID - 0376617
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (NF-kappa B)
RN  - 0 (Peg3 protein, mouse)
RN  - 0 (Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Cell Death
MH  - Cell Nucleus/metabolism
MH  - Kruppel-Like Transcription Factors
MH  - Mice
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - NF-kappa B/metabolism
MH  - Phosphorylation
MH  - *Protein Kinases
MH  - Proteins/*genetics/physiology
MH  - *Signal Transduction
MH  - *Transcription Factors
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 2000/10/25 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/25 11:00
PHST- 2000/10/25 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/25 11:00 [entrez]
AID - S0023-6837(22)02078-5 [pii]
AID - 10.1038/labinvest.3780160 [doi]
PST - ppublish
SO  - Lab Invest. 2000 Oct;80(10):1509-11. doi: 10.1038/labinvest.3780160.