PMID- 11045834
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20190817
IS  - 0277-2116 (Print)
IS  - 0277-2116 (Linking)
VI  - 31
IP  - 4
DP  - 2000 Oct
TI  - Celiac disease in a Chilean population carrying Amerindian traits.
PG  - 381-6
AB  - BACKGROUND: Although clinical manifestations of celiac disease may change 
      throughout life, clinical, histologic, immunologic, and genetic studies show that 
      there are incomplete forms of this condition, making it difficult to define the 
      disease at a given moment. Because there is no information published in the Latin 
      American-Amerindian population, this study was conducted to assess relations 
      between these parameters in Chileans with celiac disease and their first-degree 
      relatives. METHODS: Sixty-two persons with confirmed celiac disease (mean age, 
      17.9 +/- 5.1 years; 78.3% females) and 126 relatives (mean age, 27.9 +/- 17.2 
      years; 65.1% females) were evaluated. Clinical manifestations, antiendomysial 
      antibodies (EMAs), and human leukocyte antigen (HLA) haplotypes were studied in 
      patients. Additionally, jejunal biopsy specimens were assessed (light microscopy) 
      in EMA-positive (EMA+) relatives. RESULTS: Of the patients, 24.1% adhered to a 
      strict gluten-free diet; 26% were oligosymptomatic, and none were malnourished; 
      45% were EMA+; 13.8% who ingested gluten were EMA-negative (EMA-); one patient 
      consuming a strict gluten-free diet was EMA+. The DQA1*0501 allele was present in 
      the highest frequency (48%, P < 0.0005), whereas combinations of DQ8 were 
      predominant. Of the relatives, 4.8% were EMA+; they had a significantly higher 
      frequency of diarrhea, weight loss, and anorexia (P < 0.03); and all had abnormal 
      histology in biopsy specimens. CONCLUSIONS: After childhood, celiac disease is 
      oligosymptomatic and is often unrecognized by patients. Disease in 13.8% of 
      patients and in 4.8% relatives appeared as incomplete forms of celiac disease. 
      Predominance of DQ8 HLA haplotypes reflects the genetic Spanish-Mapuche heritage 
      of this population.
FAU - Araya, M
AU  - Araya M
AD  - Human Nutrition/Clinical Nutrition Department, Institute of Nutrition and Food 
      Technology, University of Chile, Santiago.
FAU - Mondragon, A
AU  - Mondragon A
FAU - Perez-Bravo, F
AU  - Perez-Bravo F
FAU - Roessler, J L
AU  - Roessler JL
FAU - Alarcon, T
AU  - Alarcon T
FAU - Rios, G
AU  - Rios G
FAU - Bergenfreid, C
AU  - Bergenfreid C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 8002-80-0 (Glutens)
SB  - IM
CIN - J Pediatr Gastroenterol Nutr. 2000 Oct;31(4):362-4. PMID: 11045829
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*blood
MH  - Biopsy
MH  - Celiac Disease/epidemiology/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Chile/epidemiology
MH  - Diagnosis, Differential
MH  - Female
MH  - Genetic Testing
MH  - Glutens/adverse effects
MH  - HLA-DQ Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Indians, South American/*genetics
MH  - Infant
MH  - Jejunum/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Surveys and Questionnaires
EDAT- 2000/10/25 11:00
MHDA- 2001/10/12 10:01
CRDT- 2000/10/25 11:00
PHST- 2000/10/25 11:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2000/10/25 11:00 [entrez]
AID - 10.1097/00005176-200010000-00010 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2000 Oct;31(4):381-6. doi: 
      10.1097/00005176-200010000-00010.