PMID- 11045836
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20221207
IS  - 0277-2116 (Print)
IS  - 0277-2116 (Linking)
VI  - 31
IP  - 4
DP  - 2000 Oct
TI  - Human leukocyte antigen class II alleles in white Brazilian patients with celiac 
      disease.
PG  - 391-4
AB  - BACKGROUND: Celiac disease (CD) is a permanent gluten intolerance disorder 
      characterized by malabsorption, intestinal mucosa villus atrophy, and crypt 
      hyperplasia. Clinical and histologic features improve in persons consuming a 
      gluten free diet. The pathogenesis of CD involves environmental, genetic, and 
      immunologic factors. METHODS: The frequencies of human leukocyte antigen (HLA) 
      class II alleles were evaluated in white Brazilian patients who had CD and 
      compared with those observed in healthy individuals from the same geographical 
      area (Ribeirao Preto, Sao Paulo) and of similar ethnic background. Twenty-five 
      patients with CD, 11 females and 14 males, and 91 control individuals were 
      studied. The HLA class II alleles were typed using amplified DNA hybridized with 
      sequence-specific primers. Statistical analysis was performed using the 
      two-tailed Fisher exact test. The relative risk (RR), etiologic fraction (EF), 
      and preventive fraction (PF) were also estimated. The EF represents the 
      attributable risk for the development of CD at the population level, whereas PF 
      represents the protective risk. RESULTS: The frequency of the HLA-DRB1*03, 
      HLA-DRB1*07, and HLA-DQB1*02 alleles was significantly increased in patients. The 
      RR conferred by these alleles was 5.35, 7.15, and 10.6, respectively, and the EF 
      was 48.7%, 44.7%, and 76%, respectively. The frequency of HLA-DQB1*06 alleles was 
      significantly decreased in CD patients, conferring an RR of 0.08 and a PF of 48%. 
      CONCLUSIONS: The results show that HLA-DRB1*03, HLA-DRB1*07, and HLA-DQB1*02 
      alleles conferred susceptibility to CD in Brazilian patients. In contrast, 
      HLADQB1*06 alleles conferred protection against development of the disease.
FAU - Silva, E M
AU  - Silva EM
AD  - Department of Pediatrics, Faculty of Medicine of Ribeirao Preto, University of 
      Sao Paulo, Brazil.
FAU - Fernandes, M I
AU  - Fernandes MI
FAU - Galvao, L C
AU  - Galvao LC
FAU - Sawamura, R
AU  - Sawamura R
FAU - Donadi, E A
AU  - Donadi EA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (HLA-D Antigens)
SB  - IM
MH  - *Alleles
MH  - Brazil
MH  - Case-Control Studies
MH  - Celiac Disease/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genes, Recessive
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-D Antigens/*genetics/immunology
MH  - Humans
MH  - Male
MH  - White People/*genetics
EDAT- 2000/10/25 11:00
MHDA- 2001/10/12 10:01
CRDT- 2000/10/25 11:00
PHST- 2000/10/25 11:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2000/10/25 11:00 [entrez]
AID - 10.1097/00005176-200010000-00012 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2000 Oct;31(4):391-4. doi: 
      10.1097/00005176-200010000-00012.