PMID- 11046016
OWN - NLM
STAT- MEDLINE
DCOM- 20001130
LR  - 20190515
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 165
IP  - 9
DP  - 2000 Nov 1
TI  - Anatomical origin of dendritic cells determines their life span in peripheral 
      lymph nodes.
PG  - 4910-6
AB  - Dendritic cells (DCs) exhibit considerable heterogeneity in their anatomical 
      location, surface phenotype, and functional properties. In this study, we 
      demonstrate that peripheral lymph nodes contain at least four major, functionally 
      separable, and independently derived, DC subsets, which can be clearly demarcated 
      by their CD11c, CD40, and CD8 expression pattern. Surprisingly, all DCs derived 
      directly from the bone marrow, the myeloid- and the lymphoid-related subsets, 
      turned over fast with t(1/2) of a couple of days. In contrast, DCs exported from 
      the skin, both dermal and epidermal, accumulated 3- to 4-fold slower, turnover 
      that is dramatically increased by cutaneous inflammation.
FAU - Ruedl, C
AU  - Ruedl C
AD  - Basel Institute for Immunology, Basel, Switzerland. Ruedl@bii.ch
FAU - Koebel, P
AU  - Koebel P
FAU - Bachmann, M
AU  - Bachmann M
FAU - Hess, M
AU  - Hess M
FAU - Karjalainen, K
AU  - Karjalainen K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Peptides)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Cell Lineage/immunology
MH  - Cell Movement/*immunology
MH  - Cell Separation
MH  - Cell Survival/immunology
MH  - Dendritic Cells/classification/*cytology/*immunology
MH  - Immunophenotyping
MH  - Lymph Nodes/*cytology/*immunology
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Organ Culture Techniques
MH  - Organ Specificity/immunology
MH  - Peptides/administration & dosage/immunology
MH  - Skin/drug effects/immunology
MH  - Skin Tests
MH  - T-Lymphocytes/immunology
EDAT- 2000/10/25 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/25 11:00
PHST- 2000/10/25 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/25 11:00 [entrez]
AID - 10.4049/jimmunol.165.9.4910 [doi]
PST - ppublish
SO  - J Immunol. 2000 Nov 1;165(9):4910-6. doi: 10.4049/jimmunol.165.9.4910.