PMID- 11049241
OWN - NLM
STAT- MEDLINE
DCOM- 20001207
LR  - 20191104
IS  - 1341-8076 (Print)
IS  - 1341-8076 (Linking)
VI  - 26
IP  - 4
DP  - 2000 Aug
TI  - Clinical applications of serum placental protein 14 (PP14) measurement in the 
      IVF-ET cycle.
PG  - 295-302
AB  - OBJECTIVE: Placental protein 14 (PP14) is known to be one of the endometrial 
      proteins that reflect endometrial functioning throughout the menstrual cycle. In 
      this study, we examined PP14 as a marker for human endometrial receptivity in 
      order to predict the outcome of in vitro fertilization and the embryo-transfer 
      (IVF-ET) cycle. PATIENTS AND METHODS: The subjects were 72 women who had 96 
      IVF-ET cycles and who were examined at Tokyo Medical University Hospital during 
      the period of January 1998 to June 1998 because of mechanical or unexplained 
      infertility for a duration of at least 2 years. Serum samples were collected from 
      all patients during treatment cycles, and serum PP14 concentrations were measured 
      by a newly established enzyme-linked immunosorbent assay (ELISA). RESULTS: In the 
      pregnant group, serum PP14 concentrations were markedly increased after ET, and a 
      significant difference between the pregnant group and the nonpregnant group was 
      observed 8 days following ET (p < 0.01). PP14 concentrations were higher in 
      patients with endometria that exhibited homogenous patterns and that were more 
      than 7 mm thicker than in other patients, as determined by ultrasound on the day 
      of oocyte collection (p < 0.005). The pregnancy rates of patients with 
      homogeneous patterns were lower than those of patients showing a trilaminar 
      pattern. No pregnancies were observed when serum PP14 concentrations were greater 
      than 6.85 U/l on the day of oocyte collection. CONCLUSION: PP14 might be a useful 
      marker for human endometrial receptivity to predict the outcome of IVF-ET cycles.
FAU - Suzuki, Y
AU  - Suzuki Y
AD  - Department of Obstetrics and Gynaecology, Tokyo Medical University Hospital, 
      Japan.
FAU - Sugiyama, R
AU  - Sugiyama R
FAU - Fukumine, N
AU  - Fukumine N
FAU - Usuda, S
AU  - Usuda S
FAU - Itoh, H
AU  - Itoh H
FAU - Isaka, K
AU  - Isaka K
FAU - Takayama, M
AU  - Takayama M
FAU - Teisner, B
AU  - Teisner B
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (Biomarkers)
RN  - 0 (Glycodelin)
RN  - 0 (Glycoproteins)
RN  - 0 (PAEP protein, human)
RN  - 0 (Pregnancy Proteins)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - *Embryo Transfer
MH  - Endometrium/diagnostic imaging/*physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fertilization in Vitro
MH  - Glycodelin
MH  - Glycoproteins/*blood
MH  - Humans
MH  - Infertility, Female/*therapy
MH  - Menstrual Cycle/*physiology
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy Proteins/*blood
MH  - Sensitivity and Specificity
MH  - Ultrasonography
EDAT- 2000/10/26 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/26 11:00
PHST- 2000/10/26 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/26 11:00 [entrez]
AID - 10.1111/j.1447-0756.2000.tb01325.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2000 Aug;26(4):295-302. doi: 
      10.1111/j.1447-0756.2000.tb01325.x.