PMID- 11049765
OWN - NLM
STAT- MEDLINE
DCOM- 20010202
LR  - 20061115
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 31
IP  - 4
DP  - 2000 Oct
TI  - Human herpesvirus 6 infection after autologous or allogeneic stem cell 
      transplantation: a single-center prospective longitudinal study of 92 patients.
PG  - 881-6
AB  - To determine the incidence and clinical relevance of active human herpesvirus 6 
      (HHV-6) infection, 92 consecutive unselected recipients of autologous or 
      allogeneic stem cell grafts were investigated in a prospective longitudinal 
      study. Active infection was assessed by the presence of viral deoxyribonucleic 
      acid (DNA) in 846 peripheral blood mononuclear cell specimens and 115 plasma 
      specimens, by means of a specially developed polymerase chain reaction designed 
      to avoid detection of latent genome. The incidence of HHV-6 infection observed 
      was 42.5%, irrespective of the type or source of graft, and infection was 
      significantly associated with partial (P=.002) or total myelosuppression (P=.01) 
      and fever (P<. 000001). Infusion of bone marrow as the source of graft, 
      reactivation occurring before platelet or neutrophil engraftment, and presence of 
      HHV-6 DNA in plasma were identified as risk factors for symptomatic HHV-6 
      infection (P<.002).
FAU - Imbert-Marcille, B M
AU  - Imbert-Marcille BM
AD  - Laboratoire de Virologie, Institut de Biologie des Hopitaux de Nantes, Nantes, 
      FRANCE. bmimbert@sante.univ-nantes.fr
FAU - Tang, X W
AU  - Tang XW
FAU - Lepelletier, D
AU  - Lepelletier D
FAU - Besse, B
AU  - Besse B
FAU - Moreau, P
AU  - Moreau P
FAU - Billaudel, S
AU  - Billaudel S
FAU - Milpied, N
AU  - Milpied N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20001025
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Base Sequence
MH  - Child
MH  - Child, Preschool
MH  - DNA Primers/genetics
MH  - DNA, Viral/blood/genetics
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Herpesviridae Infections/*etiology/transmission/virology
MH  - *Herpesvirus 6, Human/genetics/isolation & purification/pathogenicity
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
EDAT- 2000/10/26 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/10/26 11:00
PHST- 1999/10/25 00:00 [received]
PHST- 2000/01/04 00:00 [revised]
PHST- 2000/10/26 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/10/26 11:00 [entrez]
AID - CID994215 [pii]
AID - 10.1086/318142 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2000 Oct;31(4):881-6. doi: 10.1086/318142. Epub 2000 Oct 25.