PMID- 11049767
OWN - NLM
STAT- MEDLINE
DCOM- 20010202
LR  - 20041117
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 31
IP  - 4
DP  - 2000 Oct
TI  - Human herpesvirus 6 and multiple sclerosis: systemic active infections in 
      patients with early disease.
PG  - 894-903
AB  - By means of immunohistochemical staining, cells actively infected with human 
      herpesvirus 6 (HHV-6) were found in central nervous system tissues from 8 (73%) 
      of 11 patients with definite multiple sclerosis (MS). Interestingly, 17 (90%) of 
      19 tissue sections showing active demyelination were positive for HHV-6-infected 
      cells compared with only 3 (13%) of 23 tissue sections free of active disease 
      (P<.0001). Central nervous system tissues from 2 of 28 normal persons and 
      patients with other inflammatory demyelinative diseases were positive for 
      HHV-6-infected cells (P<.0001), and the 2 positive cases were diagnosed as having 
      HHV-6 leukoencephalitis. By use of a rapid culture assay, blood samples from 22 
      (54%) of 41 patients with definite MS were found to contain active HHV-6 
      infections, compared with 0 of 61 normal controls (P<.0001). No significant 
      difference was found between HHV-6 viremia-positive and HHV-6 viremia-negative MS 
      patients with respect to type of disease (relapsing/remitting or progressive). In 
      contrast, patients with active HHV-6 viremia were significantly younger and had 
      shorter durations of disease than did HHV-6 viremia-negative patients.
FAU - Knox, K K
AU  - Knox KK
AD  - Institute for Viral Pathogenesis, Milwaukee, WI 53226, USA. kknox@hhv6.com
FAU - Brewer, J H
AU  - Brewer JH
FAU - Henry, J M
AU  - Henry JM
FAU - Harrington, D J
AU  - Harrington DJ
FAU - Carrigan, D R
AU  - Carrigan DR
LA  - eng
PT  - Journal Article
DEP - 20001020
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Marrow Transplantation
MH  - Case-Control Studies
MH  - Central Nervous System/virology
MH  - Female
MH  - Herpesviridae Infections/*complications/virology
MH  - *Herpesvirus 6, Human/isolation & purification/pathogenicity
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunosuppressive Agents/adverse effects
MH  - Leukocytes/virology
MH  - Lymphoid Tissue/virology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*complications/virology
MH  - Organ Transplantation
MH  - Viremia/complications/virology
EDAT- 2000/10/26 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/10/26 11:00
PHST- 1999/10/25 00:00 [received]
PHST- 2000/02/23 00:00 [revised]
PHST- 2000/10/26 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/10/26 11:00 [entrez]
AID - CID994213 [pii]
AID - 10.1086/318141 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2000 Oct;31(4):894-903. doi: 10.1086/318141. Epub 2000 Oct 20.