PMID- 11049788
OWN - NLM
STAT- MEDLINE
DCOM- 20010202
LR  - 20220311
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 31
IP  - 4
DP  - 2000 Oct
TI  - Paracoccidioidomycosis: a model for evaluation of the effects of human 
      immunodeficiency virus infection on the natural history of endemic tropical 
      diseases.
PG  - 1032-9
AB  - The interaction of human immunodeficiency virus (HIV) infection with endemic 
      tropical diseases has become a major concern, but its mechanisms are still poorly 
      understood. Paracoccidioidomycosis (PCM), a South America endemic deep mycosis, 
      may provide an interesting model to investigate this interaction, as 
      clinical-epidemiological features of most HIV-PCM-coinfected patients are 
      difficult to classify into the standard acute and chronic forms of PCM. Such 
      patients have presented clinical features indicative of an uncontrolled infection 
      with lymphohematogenous dissemination, similar to the more severe, acute form. 
      However, this infection probably resulted from reactivated latent foci that, in 
      nonimmunocompromised hosts, leads to the less severe chronic form, characterized 
      by mucosal lesions. We propose that a new outcome of the Paracoccidioides 
      brasiliensis-host interaction is induced by concomitant HIV infection. This 
      outcome probably reflects an impaired anti-P. brasiliensis immune response during 
      coinfection that is similar to that seen in the acute form, although the patients 
      have a chronic P. brasiliensis infection.
FAU - Benard, G
AU  - Benard G
AD  - Laboratory of Medical Investigation No. 56, Hospital das Clinicas da Faculdade de 
      Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. mahong@usp.br
FAU - Duarte, A J
AU  - Duarte AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20001020
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications/etiology/pathology
MH  - Female
MH  - Humans
MH  - Immunocompetence
MH  - Male
MH  - Models, Biological
MH  - Paracoccidioides/immunology
MH  - Paracoccidioidomycosis/*complications/etiology/pathology
RF  - 77
EDAT- 2000/10/26 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/10/26 11:00
PHST- 1999/11/15 00:00 [received]
PHST- 2000/03/21 00:00 [revised]
PHST- 2000/10/26 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/10/26 11:00 [entrez]
AID - CID994282 [pii]
AID - 10.1086/318146 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2000 Oct;31(4):1032-9. doi: 10.1086/318146. Epub 2000 Oct 20.