PMID- 11050292
OWN - NLM
STAT- MEDLINE
DCOM- 20001229
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 407
IP  - 1-2
DP  - 2000 Oct 27
TI  - GABA(B) receptor mechanism and imipramine-induced antinociception in ligated and 
      non-ligated mice.
PG  - 65-72
AB  - This study concerned the effects of GABA(B) receptor agents on imipramine-induced 
      antinociception in ligated and non-ligated mice in hot-plate test. The data 
      showed that different doses of morphine (3, 6 and 9 mg/kg) induced a 
      dose-dependent antinociception in non-ligated or ligated mice. However, the 
      opioid response was decreased in the ligated animals. Intracerebroventricular 
      (i.c.v.) administration of imipramine (5, 10, 20 and 40 microg/mouse) did not 
      induce antinociception in either non-ligated or ligated mice. However, the 
      response induced in the ligated mice was less than that induced in the 
      non-ligated animals. Intraperitoneal (i.p.) administration of imipramine (10, 20, 
      30 and 40 mg/kg) induced antinociception in both ligated and non-ligated animals. 
      The responses to the drug were not significantly different in the two groups. 
      Administration of baclofen either i.c.v. (0.125, 0.25 and 0. 5 microg/mouse) or 
      i.p. (0.5, 1, 2 and 4 mg/kg) induced antinociception. The response to the drug 
      was not significantly different in ligated and non-ligated mice. I.c.v. 
      administration of a lower dose of baclofen (0.125 microg/mouse) with different 
      doses of imipramine (2.5, 5 and 10 mg/kg) potentiates the response of imipramine. 
      This effect was reduced by i.c.v. injection of GABA(B) receptor antagonist, 
      CGP35348 [P-(3-aminopropyl)-p-diethoxymethyl-phosphinic acid] (20 microg/mouse). 
      The higher dose of antagonist (20 microg/mouse) also decreased the response 
      induced by baclofen or imipramine. CGP35348 itself (2.5, 5, 10 and 20 
      microg/mouse) induced dose-dependent antinociception with no significant 
      difference in the ligated and non-ligated mice. It is concluded that a GABA 
      receptor mechanism(s) may modulate the antidepressant-induced antinociception.
FAU - Zarrindast, M
AU  - Zarrindast M
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Science, P.O. Box 13145-784, Tehran, Iran. zarinmr@ams.ac.ir
FAU - Valizadeh, S
AU  - Valizadeh S
FAU - Sahebgharani, M
AU  - Sahebgharani M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - 0 (GABA Agonists)
RN  - 0 (GABA Antagonists)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Receptors, GABA-B)
RN  - 76I7G6D29C (Morphine)
RN  - 87TI61875H (CGP 35348)
RN  - H789N3FKE8 (Baclofen)
RN  - OGG85SX4E4 (Imipramine)
SB  - IM
MH  - Analgesics, Opioid/pharmacology
MH  - Animals
MH  - Antidepressive Agents, Tricyclic/*pharmacology
MH  - Baclofen/pharmacology
MH  - GABA Agonists/*pharmacology
MH  - GABA Antagonists/*pharmacology
MH  - Imipramine/*pharmacology
MH  - Ligation
MH  - Male
MH  - Mice
MH  - Morphine/pharmacology
MH  - Organophosphorus Compounds/pharmacology
MH  - Pain Measurement/*drug effects
MH  - Receptors, GABA-B/*drug effects/physiology
MH  - Sciatic Nerve/injuries
EDAT- 2000/10/26 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/26 11:00
PHST- 2000/10/26 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/26 11:00 [entrez]
AID - S0014299900006488 [pii]
AID - 10.1016/s0014-2999(00)00648-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2000 Oct 27;407(1-2):65-72. doi: 10.1016/s0014-2999(00)00648-8.