PMID- 11052927
OWN - NLM
STAT- MEDLINE
DCOM- 20010315
LR  - 20131121
IS  - 0143-5221 (Print)
IS  - 0143-5221 (Linking)
VI  - 99
IP  - 5
DP  - 2000 Nov
TI  - Plasma bradykinin levels in human chronic congestive heart failure.
PG  - 461-6
AB  - Induction of congestive heart failure by high-frequency pacing has been reported 
      to increase plasma levels of immunoreactive kinins in dogs. In the present study, 
      we evaluated plasma bradykinin levels in human heart failure. Utilizing a 
      recently developed method, we specifically measured plasma levels of 
      bradykinin-(1-9) nonapeptide in 21 patients with chronic congestive heart failure 
      [New York Heart Association (NYHA) stages III and IV). At the same time, we 
      measured plasma atrial natriuretic peptide levels and plasma renin activity, and, 
      as a marker of inflammation, plasma levels of tumour necrosis factor. In 
      addition, 18 healthy subjects matched for gender and age served as normal 
      controls. Plasma bradykinin concentrations were not higher in patients with 
      chronic congestive heart failure (median 2.1 fmol/ml) than in healthy subjects 
      (2.6 fmol/ml). In contrast, plasma atrial natriuretic peptide levels were clearly 
      higher (patients, 63 fmol/ml; controls, 24 fmol/ml; P<0.0001), despite diuretic 
      treatment and in the presence of high plasma renin activity (patients, 13.0 ng x 
      h(-1) x ml(-1); controls, 0.3 ng x h(-1) x ml(-1); P<0.0001). Tumour necrosis 
      factor was elevated in heart failure patients in NYHA class IV only (27 pg/ml, 
      compared with 21 pg/ml in controls; P=0.013). Bradykinin, atrial natriuretic 
      peptide and plasma renin activity levels were not correlated with the severity of 
      the disease, as assessed by NYHA classification. These results indicate that a 
      rather selective cytokine activation, without concomitant stimulation of the 
      kallikrein-kinin system, occurs in human chronic congestive heart failure.
FAU - Cugno, M
AU  - Cugno M
AD  - Department of Internal Medicine, University of Milan, IRCCS Maggiore Hospital, 
      Milan, Italy.
FAU - Agostoni, P
AU  - Agostoni P
FAU - Brunner, H R
AU  - Brunner HR
FAU - Gardinali, M
AU  - Gardinali M
FAU - Agostoni, A
AU  - Agostoni A
FAU - Nussberger, J
AU  - Nussberger J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - EC 3.4.23.15 (Renin)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Atrial Natriuretic Factor/blood
MH  - Bradykinin/*blood
MH  - Case-Control Studies
MH  - Chromatography, High Pressure Liquid
MH  - Female
MH  - Heart Failure/*blood/classification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rabbits
MH  - Renin/blood
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2000/10/29 11:00
MHDA- 2001/03/17 10:01
CRDT- 2000/10/29 11:00
PHST- 2000/10/29 11:00 [pubmed]
PHST- 2001/03/17 10:01 [medline]
PHST- 2000/10/29 11:00 [entrez]
PST - ppublish
SO  - Clin Sci (Lond). 2000 Nov;99(5):461-6.