PMID- 11055001
OWN - NLM
STAT- MEDLINE
DCOM- 20001109
LR  - 20131121
IS  - 0003-9683 (Print)
IS  - 0003-9683 (Linking)
VI  - 93
IP  - 9
DP  - 2000 Sep
TI  - [Vasodilator effects of bradykinin on the resistive circulation of the forearm of 
      coronary patients].
PG  - 1103-8
AB  - This study was undertaken to determine the vascular effects of bradykinin and its 
      modes of action on the resistive circulation of the forearms of coronary patients 
      and healthy volunteers. Two groups were studied: Group I comprising 8 coronary 
      patients with normal left ventricular function and Group II with 8 healthy 
      volunteers. The method of measurement of forearm blood flow was occlusive venous 
      plethysmography with a mercury strain gauge. The vasodilatory response of the two 
      groups to local arterial perfusion of acetylcholine (40 and 80 micrograms/min), 
      bradykinin (10, 30, 100 pmoles/min), then the association of 
      L-Ng-monomethyl-L-arginine (L-NMMA) at 8 microG/min, an inhibitor of the 
      synthesis of nitric oxide, with acetylcholine and bradykinin. Five subjects of 
      the control group received oral aspirin (250 mg/day) for one week before the 
      study. Acetylcholine and bradykinin increased forearm flow in a dose-dependent 
      manner but the increase was significantly less in coronary patients than in the 
      healthy volunteers (p < 0.05). The L-NMMA inhibited the vasodilatory response to 
      acetylcholine by about 40% in the two groups but had no significant effect on the 
      vasodilatation induced by bradykinin. Aspirin had no effect on the vasodilatation 
      induced by acetylcholine or bradykinin. These data show that the vasodilatory 
      response to bradykinin is decreased in coronary patients and suggest that nitric 
      oxide is not the second main messenger of bradykinin in the resistive circulation 
      of the forearm.
FAU - Benacerraf, S
AU  - Benacerraf S
AD  - Service d'explorations fonctionnelles cardiologiques, hopital intercommunal de 
      Creteil, Federation de cardiologie de l'hopital Henri-Mondor, Creteil.
FAU - Carville, C
AU  - Carville C
FAU - Sediame, S
AU  - Sediame S
FAU - Belhassen, L
AU  - Belhassen L
FAU - Adnot, S
AU  - Adnot S
FAU - Dubois-Rande, J L
AU  - Dubois-Rande JL
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Effet vasodilatateur de la bradykinine au niveau de la circulation resistive de 
      l'avant-bras de patients coronariens.
PL  - France
TA  - Arch Mal Coeur Vaiss
JT  - Archives des maladies du coeur et des vaisseaux
JID - 0406011
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 27JT06E6GR (omega-N-Methylarginine)
RN  - N9YNS0M02X (Acetylcholine)
RN  - R16CO5Y76E (Aspirin)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Acetylcholine/administration & dosage/*pharmacology
MH  - Adult
MH  - Aged
MH  - Aspirin/pharmacology
MH  - Bradykinin/administration & dosage/*pharmacology
MH  - Coronary Disease/*physiopathology
MH  - Forearm/*blood supply
MH  - Humans
MH  - Infusions, Intra-Arterial
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation Inhibitors/pharmacology
MH  - Reference Values
MH  - Regional Blood Flow/*drug effects
MH  - Vasodilation/*drug effects/physiology
MH  - omega-N-Methylarginine/administration & dosage/*pharmacology
EDAT- 2000/10/31 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/31 11:00
PHST- 2000/10/31 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/31 11:00 [entrez]
PST - ppublish
SO  - Arch Mal Coeur Vaiss. 2000 Sep;93(9):1103-8.