PMID- 11055648
OWN - NLM
STAT- MEDLINE
DCOM- 20010322
LR  - 20190826
IS  - 0036-5548 (Print)
IS  - 0036-5548 (Linking)
VI  - 32
IP  - 5
DP  - 2000
TI  - Mononuclear cells and cytokines in the cerebrospinal fluid of echovirus 30 
      meningitis patients.
PG  - 471-4
AB  - The local immune response to echovirus 30 meningitis in children was investigated 
      in 2 ways: using flow cytometry to examine the mononuclear cell and lymphocyte 
      subsets and enzyme-linked immunosorbent assays to examine the cerebrospinal fluid 
      (CSF) levels of cytokines, including monocyte chemoattractant protein-1 (MCP-1), 
      interferon gamma (IFN-gamma) and interleukin-12 (IL-12). The numbers of 
      macrophages in the CSF were increased, in particular during the early part of the 
      acute stage. The levels of MCP-1, which is responsible for the accumulation of 
      macrophages, as well as those of IFN-gamma and IL-12, which play important roles 
      in the activation of macrophages and T helper (Th) 1 cells, respectively, were 
      increased in the CSF of patients compared with the levels found in the controls. 
      Likewise, numbers of activated CD4 + and CD8 + T lymphocytes were increased in 
      the CSF. Since the ratio of CD4/CD8 correlated with the age of the patients, CD8 
      + T lymphocytes in the CSF might play a more important role in younger children.
FAU - Matsubara, T
AU  - Matsubara T
AD  - Department of Pediatrics, Yamaguchi University School of Medicine, Ubhe, Japan.
FAU - Matsuoka, T
AU  - Matsuoka T
FAU - Katayama, K
AU  - Katayama K
FAU - Yoshitomi, T
AU  - Yoshitomi T
FAU - Nishikawa, M
AU  - Nishikawa M
FAU - Ichiyama, T
AU  - Ichiyama T
FAU - Furukawa, S
AU  - Furukawa S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Infect Dis
JT  - Scandinavian journal of infectious diseases
JID - 0215333
RN  - 0 (Cytokines)
SB  - IM
MH  - Cerebrospinal Fluid/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*cerebrospinal fluid
MH  - Echovirus Infections/cerebrospinal fluid/*immunology/virology
MH  - Enterovirus B, Human/*immunology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Leukocytes, Mononuclear/cytology/*immunology
MH  - Lymphocyte Activation
MH  - Lymphocyte Subsets
MH  - Male
MH  - Meningitis, Viral/cerebrospinal fluid/*immunology/virology
EDAT- 2000/10/31 11:00
MHDA- 2001/03/27 10:01
CRDT- 2000/10/31 11:00
PHST- 2000/10/31 11:00 [pubmed]
PHST- 2001/03/27 10:01 [medline]
PHST- 2000/10/31 11:00 [entrez]
AID - 10.1080/003655400458712 [doi]
PST - ppublish
SO  - Scand J Infect Dis. 2000;32(5):471-4. doi: 10.1080/003655400458712.