PMID- 11055893
OWN - NLM
STAT- MEDLINE
DCOM- 20010215
LR  - 20191104
IS  - 0037-1963 (Print)
IS  - 0037-1963 (Linking)
VI  - 37
IP  - 3 Suppl 5
DP  - 2000 Jul
TI  - Management of thromboembolism in the outpatient setting.
PG  - 23-6
AB  - Low-molecular-weight heparins (LMWHs) are suitable for self-administration at 
      home, because they have a predictable anticoagulant effect following subcutaneous 
      injection and do not require laboratory monitoring. Clinical trials evaluating 
      the safety and efficacy of LMWHs in the outpatient setting for the prevention of 
      deep vein thrombosis (DVT) after orthopedic surgery and for the treatment of 
      established DVT are reviewed. Extended LMWH prophylaxis reduces the incidence of 
      venographically detected DVT by approximately 50%. Medical practice relies 
      heavily on clinical diagnosis of DVT, for which both sensitivity and specificity 
      are poor. It is uncertain how the results of research trials on DVT prevention 
      based on venography relate to ordinary practice. In the treatment of established 
      DVT, there was no significant difference between outpatient management with LMWH 
      and inpatient treatment with unfractionated heparin (UFH). However, outpatient 
      management offered a considerable reduction in resource usage, with associated 
      cost savings.
FAU - Agnelli, G
AU  - Agnelli G
AD  - Department of Internal Medicine, Institute of Internal and Vascular Medicine, 
      University of Perugia, Italy.
FAU - Rossi, R
AU  - Rossi R
FAU - Santamaria, M G
AU  - Santamaria MG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Hematol
JT  - Seminars in hematology
JID - 0404514
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - *Ambulatory Care
MH  - Anticoagulants/therapeutic use
MH  - Heparin/therapeutic use
MH  - Heparin, Low-Molecular-Weight/therapeutic use
MH  - Humans
MH  - Thromboembolism/*prevention & control/*therapy
MH  - Venous Thrombosis/*prevention & control/*therapy
RF  - 14
EDAT- 2000/10/31 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/10/31 11:00
PHST- 2000/10/31 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/10/31 11:00 [entrez]
AID - S0037-1963(00)90097-0 [pii]
AID - 10.1016/s0037-1963(00)90097-0 [doi]
PST - ppublish
SO  - Semin Hematol. 2000 Jul;37(3 Suppl 5):23-6. doi: 10.1016/s0037-1963(00)90097-0.