PMID- 11059901
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 11
IP  - 15
DP  - 2000 Oct 20
TI  - Neurobehavioural effects of hypergravity conditions in the adult mouse.
PG  - 3353-6
AB  - To evaluate the behavioural response to a hypergravity condition in CD-1 mice, 
      young adult subjects of both sexes were exposed to 2 g for a single 60 min 
      rotational session. Motion sickness (MS) and ethological-type scoring of 
      different activities were used to evaluate the behavioural response. Nerve growth 
      factor (NGF) and brain derived neurotrophic factor (BDNF) levels were also 
      assessed. Behavioural scores indicated a transient mild sickness associated with 
      hypergravity, with reduction in spontaneous activity. In males kaolin consumption 
      (a MS index) increased following rotation while females consumed more kaolin 
      irrespective of whether they have been rotated or simply exposed to the noise and 
      vibration of the rotational apparatus. In males, hypothalamic NGF levels were 
      markedly increased after rotation while no major changes were observed in central 
      BDNF expression. These results indicate mice may represent a suitable MS model.
FAU - Santucci, D
AU  - Santucci D
AD  - Behavioural Pathophysiology Section, Laboratorio di Fisiopatologia di Organo e di 
      Sistema, Istituto Superiore di Sanita', Rome, Italy.
FAU - Corazzi, G
AU  - Corazzi G
FAU - Francia, N
AU  - Francia N
FAU - Antonelli, A
AU  - Antonelli A
FAU - Aloe, L
AU  - Aloe L
FAU - Alleva, E
AU  - Alleva E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 24H4NWX5CO (Kaolin)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Brain/metabolism
MH  - Eating
MH  - Female
MH  - *Hypergravity
MH  - Kaolin
MH  - Male
MH  - Mice
MH  - Motion Sickness/etiology/psychology
MH  - Nerve Growth Factor/metabolism
MH  - *Nervous System Physiological Phenomena
MH  - Pica/etiology/physiopathology
MH  - Rotation
MH  - Sex Characteristics
MH  - Tissue Distribution
EDAT- 2000/11/04 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/11/04 11:00
PHST- 2000/11/04 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/11/04 11:00 [entrez]
AID - 10.1097/00001756-200010200-00018 [doi]
PST - ppublish
SO  - Neuroreport. 2000 Oct 20;11(15):3353-6. doi: 10.1097/00001756-200010200-00018.