PMID- 11059949
OWN - NLM
STAT- MEDLINE
DCOM- 20001212
LR  - 20151119
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 94
IP  - 10
DP  - 2000 Oct
TI  - Human leucocyte antigens (HLA) and trimellitic anhydride (TMA) immunological lung 
      disease.
PG  - 964-70
AB  - Occupational immunological lung disease, due to low molecular weight, reactive 
      chemicals such as trimellitic anhydride (TMA), is an emerging health problem. If 
      there were a marker that was highly predictive of the ability of the immune 
      system to recognize TMA as an allergen, better prevention strategies could be 
      employed with at risk individuals. The purpose of this study is to evaluate 
      whether human leucocyte antigen (HLA) class specificity is associated with the 
      development of late respiratory systemic syndrome (LRSS) or asthma due to 
      immunological sensitivity to trimellitic anhydride (TMA). This is a case control 
      study of 17 individuals with LRSS, 12 with asthma and 22 TMA similarly exposed 
      individuals who did not develop LRSS or asthma. Comparing the sensitized 
      individuals (LRSS or asthma) with the non-sensitized individuals (controls), we 
      found no difference in frequency of any HLA antigen. In summary, the lack of 
      association of HLA antigens with LRSS or asthma due to TMA suggests that these 
      will not be useful markers to identify at risk individuals.
FAU - Grammer, L C
AU  - Grammer LC
AD  - Department of Medicine of Northwestern Memorial Hospital and Northwestern 
      University Medical School, Chicago, Illinois 60611, USA.
FAU - Zeiss, C R
AU  - Zeiss CR
FAU - Yarnold, P R
AU  - Yarnold PR
FAU - Shaughnessy, M A
AU  - Shaughnessy MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Phthalic Anhydrides)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 80T61EUU7H (trimellitic anhydride)
SB  - IM
MH  - Adult
MH  - Allergens/*adverse effects
MH  - Asthma/chemically induced/*diagnosis/immunology
MH  - Biomarkers/analysis
MH  - Case-Control Studies
MH  - Female
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Occupational Diseases/chemically induced/*diagnosis/immunology
MH  - Occupational Exposure/adverse effects
MH  - Phthalic Anhydrides/*adverse effects
MH  - Respiration Disorders/chemically induced/*diagnosis/immunology
EDAT- 2000/11/04 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/04 11:00
PHST- 2000/11/04 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/04 11:00 [entrez]
AID - S0954-6111(00)90866-7 [pii]
AID - 10.1053/rmed.2000.0866 [doi]
PST - ppublish
SO  - Respir Med. 2000 Oct;94(10):964-70. doi: 10.1053/rmed.2000.0866.