PMID- 11059964
OWN - NLM
STAT- MEDLINE
DCOM- 20001108
LR  - 20190906
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 94 Suppl F
DP  - 2000 Oct
TI  - The effect of long-acting beta2-agonists on airway inflammation in asthmatic 
      patients.
PG  - S22-5
AB  - Early observations suggested that the inhibition by long-acting beta2-agonists 
      (LABAs) of non-specific bronchial hyperresponsiveness following allergen 
      challenge was unrelated to bronchodilation or functional antagonism and might be 
      a reflection of anti-inflammatory activity. Investigation of the effect of LABAs 
      on airway inflammatory responses has demonstrated an inhibition of eosinophil 
      recruitment in allergen challenge studies. Nevertheless, results from biopsy and 
      other studies suggest that the chronic inflammatory process in asthma patients is 
      unaffected by these drugs. There is no evidence from biopsy studies that LABAs 
      are pro-inflammatory or that they mask existing inflammation. The beneficial 
      effects of LABAs in allergen challenge are probably mediated through 
      stabilization of mast cells. Recent evidence suggests that LABAs may reduce 
      numbers of neutrophils and their associated markers; this observation needs to be 
      confirmed in future studies and its relevance to the treatment of asthma 
      determined.
FAU - Howarth, P H
AU  - Howarth PH
AD  - Division of Respiratory Cell and Molecular Biology, Department of Medical 
      Specialities, Southampton General Hospital, UK. phh1@soton.ac.uk
FAU - Beckett, P
AU  - Beckett P
FAU - Dahl, R
AU  - Dahl R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Adrenergic beta-Agonists)
RN  - 6EW8Q962A5 (Salmeterol Xinafoate)
RN  - QF8SVZ843E (Albuterol)
SB  - IM
MH  - Adrenergic beta-Agonists/pharmacology/*therapeutic use
MH  - Albuterol/analogs & derivatives/pharmacology/therapeutic use
MH  - Asthma/*drug therapy
MH  - Bronchitis/etiology
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Chronic Disease
MH  - Eosinophils/drug effects
MH  - Humans
MH  - Lymphocytes/drug effects
MH  - Mast Cells/drug effects
MH  - Neutrophils/drug effects
MH  - Salmeterol Xinafoate
RF  - 33
EDAT- 2000/11/04 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/04 11:00
PHST- 2000/11/04 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/04 11:00 [entrez]
AID - S0954-6111(00)90129-X [pii]
AID - 10.1016/s0954-6111(00)90129-x [doi]
PST - ppublish
SO  - Respir Med. 2000 Oct;94 Suppl F:S22-5. doi: 10.1016/s0954-6111(00)90129-x.