PMID- 11062717
OWN - NLM
STAT- MEDLINE
DCOM- 20001211
LR  - 20131121
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 20
IP  - 5A
DP  - 2000 Sep-Oct
TI  - Fluorovisualization effect of acridine orange on mouse osteosarcoma.
PG  - 3019-24
AB  - If the localization of musculoskeletal sarcomas could be visualized during 
      surgery, it would be possible to completely resect the tumor with minimum damage 
      to normal tissues and the patients could retain a functional limb. Therefore, we 
      conducted the present study to clarify the usefulness of acridine orange (AO) for 
      fluorovisualization of tumors using a mouse osteosarcoma model. At 2 hours after 
      injection of 10 mg/kg AO to mice inoculated with MOS mouse osteosarcoma cells, 
      fluorovisualization of mouse osteosarcoma reached the maximum level. Even a 
      1-mm-diameter lesion of pulmonary metastasis was visualized. The results 
      suggested that AO may be useful for specific fluorovisualization of human 
      osteosarcomas during surgery.
FAU - Kusuzaki, K
AU  - Kusuzaki K
AD  - Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, 
      Japan.
FAU - Suginoshita, T
AU  - Suginoshita T
FAU - Minami, G
AU  - Minami G
FAU - Aomori, K
AU  - Aomori K
FAU - Takeshita, H
AU  - Takeshita H
FAU - Murata, H
AU  - Murata H
FAU - Hashiguchi, S
AU  - Hashiguchi S
FAU - Ashihara, T
AU  - Ashihara T
FAU - Hirasawa, Y
AU  - Hirasawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Fluorescent Dyes)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - *Acridine Orange
MH  - Animals
MH  - Bone Neoplasms/*pathology
MH  - Disease Models, Animal
MH  - Fluorescence
MH  - *Fluorescent Dyes
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Osteosarcoma/*pathology
EDAT- 2000/11/04 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/04 11:00
PHST- 2000/11/04 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/04 11:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2000 Sep-Oct;20(5A):3019-24.