PMID- 11063784
OWN - NLM
STAT- MEDLINE
DCOM- 20010111
LR  - 20190826
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 96
IP  - 2
DP  - 2000 Oct 30
TI  - Cocaine use and the mid-latency auditory evoked responses.
PG  - 117-26
AB  - To examine the effects of chronic cocaine use on the mid-latency auditory evoked 
      responses (MLAERs), we recorded the evoked responses of 15 cocaine-dependent 
      subjects and 13 age-matched healthy control subjects. Two evoked response 
      paradigms were used: a trains paradigm with four different inter-stimulus 
      intervals (ISIs) and a paired-click paradigm. Our data suggest that 
      cocaine-dependent subjects generate smaller P50 components when long ISIs are 
      used with multiple repetitions (in the trains paradigm). In a single repetition 
      paradigm (paired clicks), a significant decrease in the ability to attenuate the 
      N100 component was seen in the cocaine-dependent subjects.
FAU - Boutros, N
AU  - Boutros N
AD  - Department of Psychiatry (116A), Yale University School of Medicine and VA 
      Connecticut Healthcare System, 950 Campbell Avenue, 06516, West Haven, CT, USA. 
      nash@boutros@yale.edu
FAU - Campbell, D
AU  - Campbell D
FAU - Petrakis, I
AU  - Petrakis I
FAU - Krystal, J
AU  - Krystal J
FAU - Caporale, M
AU  - Caporale M
FAU - Kosten, T
AU  - Kosten T
LA  - eng
GR  - DA10347-02/DA/NIDA NIH HHS/United States
GR  - P50-DA04060/DA/NIDA NIH HHS/United States
GR  - P50-DA9250/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acoustic Stimulation
MH  - Adult
MH  - Arousal/drug effects/physiology
MH  - Attention/drug effects/physiology
MH  - Brain Mapping
MH  - Cerebral Cortex/drug effects/physiopathology
MH  - Cocaine-Related Disorders/*physiopathology
MH  - Dopamine/physiology
MH  - Electroencephalography/drug effects
MH  - Evoked Potentials, Auditory/*drug effects/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Norepinephrine/physiology
MH  - Reaction Time/*drug effects/physiology
MH  - Reference Values
MH  - Signal Processing, Computer-Assisted
EDAT- 2000/11/07 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/07 11:00
PHST- 2000/11/07 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/07 11:00 [entrez]
AID - S0165-1781(00)00207-9 [pii]
AID - 10.1016/s0165-1781(00)00207-9 [doi]
PST - ppublish
SO  - Psychiatry Res. 2000 Oct 30;96(2):117-26. doi: 10.1016/s0165-1781(00)00207-9.