PMID- 11063795
OWN - NLM
STAT- MEDLINE
DCOM- 20001204
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 121
IP  - 2
DP  - 2000 Sep
TI  - Unusual breakpoint distribution of 8p abnormalities in T-prolymphocytic leukemia: 
      a study with YACS mapping to 8p11-p12.
PG  - 128-32
AB  - Chromosome 8 abnormalities are seen in 80% of patients with T-cell prolymphocytic 
      leukemia (T-PLL). The abnormalities described are 
      idic(8)(p11),t(8;8)(p11;q12),+8, and 8p+ with the involvement of 8p. To localize 
      8p11-p12 breakpoints in T-PLL, metaphases from seven cases were karyotyped. Those 
      with idic(8)(p11) and add(8)(p11) were probed with a panel of contiguous YACs 
      derived from 8p11-p12 using fluorescence in situ hybridization (FISH). Analysis 
      of FISH results showed that 8p11-p12 breakpoints cluster into two regions. The 
      first region is telomeric to YAC 899e2, which contains the fibroblast growth 
      factor receptor-1 gene (FGFR1) and appears to cluster within a 1.5-MB YAC 807a2. 
      The second region is more centromeric with breakpoints on either side of YAC 
      806e9, flanked by YAC 940f10 distally and YAC 910d7 proximally, the latter 
      containing the MOZ gene. These findings showed that a segment of 8p was still 
      present in the isodicentric, but the pattern of clustering does not seem to 
      correspond to a breakpoint affecting a single gene. The clustering regions are 
      likely to be hot spots for recombination and result in idic(8)(p11) and 8p+. 
      These changes point to the pathogenesis of T-PLL involving deletion of a gene 
      sequence on 8p and/or gain of a copy of 8q.
FAU - Sorour, A
AU  - Sorour A
AD  - Academic Department of Haematology and Cytogenetics, Royal Marsden NHS Trust, The 
      Institute of Cancer Research, London, United Kingdom.
FAU - Brito-Babapulle, V
AU  - Brito-Babapulle V
FAU - Smedley, D
AU  - Smedley D
FAU - Yuille, M
AU  - Yuille M
FAU - Catovsky, D
AU  - Catovsky D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - *Chromosomes, Human, Pair 8
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Prolymphocytic/*genetics
MH  - Leukemia, T-Cell/*genetics
EDAT- 2000/11/07 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/07 11:00
PHST- 2000/11/07 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/07 11:00 [entrez]
AID - S0165-4608(00)00239-9 [pii]
AID - 10.1016/s0165-4608(00)00239-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Sep;121(2):128-32. doi: 
      10.1016/s0165-4608(00)00239-9.