PMID- 11063796
OWN - NLM
STAT- MEDLINE
DCOM- 20001204
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 121
IP  - 2
DP  - 2000 Sep
TI  - Reciprocal translocation (3;5)(q26;q22) and possible BCHE gene involvement in an 
      unusual myelogenous disorder with both myeloproliferative and dysplastic 
      features.
PG  - 133-8
AB  - We report on a 77-year-old male patient who presented with an unusual myelogenous 
      disorder exhibiting both myeloproliferative and dysplastic features. The patient 
      suffered from leukocytosis, eosinophilia, basophilia, transfusion dependent 
      anemia, and rapidly progressing thrombocytopenia. Classical chromosome analysis 
      and fluorescence in situ hybridization (FISH) revealed a reciprocal 
      t(3;5)(q26;q22). Using yeast artificial chromosome (YAC) probes, the breakpoint 
      on chromosome 3 was localized to the butyrylcholinesterase (BCHE) gene 
      (3q26.1-q26.2). This gene has recently been implicated in the regulation of 
      myeloid cells. Whether the BCHE gene was also involved in the deregulation of 
      myelopoiesis, causing the unusual clinical picture in this case, remains unknown.
FAU - Fureder, W
AU  - Fureder W
AD  - Department of Internal Medicine I, Division of Hematology & Hemostaseology, 
      University of Vienna, Vienna, Austria.
FAU - Streubel, B
AU  - Streubel B
FAU - Jordan, J H
AU  - Jordan JH
FAU - Walchshofer, S
AU  - Walchshofer S
FAU - Wimazal, F
AU  - Wimazal F
FAU - Jager, U
AU  - Jager U
FAU - Geissler, K
AU  - Geissler K
FAU - Schwartz, L B
AU  - Schwartz LB
FAU - Chott, A
AU  - Chott A
FAU - Lechner, K
AU  - Lechner K
FAU - Valent, P
AU  - Valent P
FAU - Fonatsch, C
AU  - Fonatsch C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 3.1.1.8 (Butyrylcholinesterase)
SB  - IM
MH  - Aged
MH  - Butyrylcholinesterase/*genetics
MH  - Chromosome Banding
MH  - *Chromosomes, Human, Pair 3
MH  - *Chromosomes, Human, Pair 5
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Myelodysplastic Syndromes/*genetics
MH  - Stem Cells
MH  - *Translocation, Genetic
EDAT- 2000/11/07 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/07 11:00
PHST- 2000/11/07 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/07 11:00 [entrez]
AID - S0165-4608(00)00245-4 [pii]
AID - 10.1016/s0165-4608(00)00245-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Sep;121(2):133-8. doi: 
      10.1016/s0165-4608(00)00245-4.