PMID- 11063830
OWN - NLM
STAT- MEDLINE
DCOM- 20001222
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 111
IP  - 1-2
DP  - 2000 Nov 1
TI  - Neurobehavioral alterations in mice with a targeted deletion of the tumor 
      necrosis factor-alpha gene: implications for emotional behavior.
PG  - 131-8
AB  - Tumor necrosis factor-alpha (TNF-alpha) is emerging as an important modulator of 
      the function of the central nervous system. In the present study, we investigated 
      a role of endogenous TNF-alpha in cognitive and emotional function using mice 
      with targeted deletions of the TNF-alpha gene. TNF-alpha-(-/-) mice showed normal 
      diurnal rhythms of spontaneous locomotor activity and cognitive functions. 
      Emotional behavior in the mutant mice, however, was significantly altered, which 
      manifested in the performance in the open-field, elevated plus maze, and forced 
      swimming tests. The altered performance in the elevated plus maze test was 
      significantly alleviated by treatment with diazepam. Postmortem brain analysis of 
      TNF-alpha-(-/-) mice revealed a significant increase in serotonin metabolism in 
      the brain. These findings suggest a role for endogenous TNF-alpha in emotional 
      behavior, which may possibly be related to alterations of serotonine metabolism.
FAU - Yamada, K
AU  - Yamada K
AD  - Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University 
      School of Medicine, 466-8560, Nagoya, Japan.
FAU - Iida, R
AU  - Iida R
FAU - Miyamoto, Y
AU  - Miyamoto Y
FAU - Saito, K
AU  - Saito K
FAU - Sekikawa, K
AU  - Sekikawa K
FAU - Seishima, M
AU  - Seishima M
FAU - Nabeshima, T
AU  - Nabeshima T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 333DO1RDJY (Serotonin)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Anxiety/immunology/physiopathology
MH  - Behavior, Animal/physiology
MH  - Brain Chemistry/immunology
MH  - Cognition/physiology
MH  - Corticosterone/blood
MH  - Emotions/*physiology
MH  - *Gene Deletion
MH  - Locomotion/physiology
MH  - Maze Learning/physiology
MH  - Memory/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Rats
MH  - Serotonin/metabolism
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2000/11/07 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/07 11:00
PHST- 2000/11/07 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/07 11:00 [entrez]
AID - S0165572800003751 [pii]
AID - 10.1016/s0165-5728(00)00375-1 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2000 Nov 1;111(1-2):131-8. doi: 10.1016/s0165-5728(00)00375-1.