PMID- 11063840
OWN - NLM
STAT- MEDLINE
DCOM- 20001222
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 111
IP  - 1-2
DP  - 2000 Nov 1
TI  - MHC antigen expression in human first trimester spinal cord with implications for 
      clinical transplantation procedures.
PG  - 210-4
AB  - We report human leukocyte antigen (HLA) class I expression in 5-17% and class II 
      in 0-9% of first trimester human spinal cord cells. After 8 days in culture with 
      gamma-interferon, >87% of the spinal cord cells expressed HLA class II. However, 
      mixed cultures of adult human peripheral lymphocytes and immature human spinal 
      cord cells, showed no induction of lymphocyte proliferation prior to or after 
      gamma-interferon exposure in culture. In conclusion, we report non-immunogenic 
      expression of HLA antigens in the human first trimester spinal cord.
FAU - Akesson, E
AU  - Akesson E
AD  - Department of NEUROTEC, Karolinska Institutet, Huddinge University Hospital, KFC 
      4th floor, S-141 86, Novum, Sweden. elisabet.akesson@neurotec.ki.se
FAU - Markling, L
AU  - Markling L
FAU - Kjaeldgaard, A
AU  - Kjaeldgaard A
FAU - Falci, S
AU  - Falci S
FAU - Ringden, O
AU  - Ringden O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Antineoplastic Agents/pharmacology
MH  - Cell Division/drug effects/immunology
MH  - Cells, Cultured
MH  - Fetal Tissue Transplantation/*immunology
MH  - Fetus/cytology/immunology/metabolism
MH  - Gestational Age
MH  - Histocompatibility Antigens Class I/analysis/*biosynthesis
MH  - Humans
MH  - Interferon-gamma/pharmacology
MH  - Lymphocytes/cytology/immunology/metabolism
MH  - Spinal Cord/embryology/*immunology/*transplantation
EDAT- 2000/11/07 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/07 11:00
PHST- 2000/11/07 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/07 11:00 [entrez]
AID - S0165572800003830 [pii]
AID - 10.1016/s0165-5728(00)00383-0 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2000 Nov 1;111(1-2):210-4. doi: 10.1016/s0165-5728(00)00383-0.