PMID- 11066106 OWN - NLM STAT- MEDLINE DCOM- 20001212 LR - 20191104 IS - 1522-1946 (Print) IS - 1522-1946 (Linking) VI - 51 IP - 3 DP - 2000 Nov TI - Coronary flow reserve is reflective of myocardial perfusion status in acute anterior myocardial infarction. PG - 281-6 AB - Our objective was to determine whether coronary vasodilatory reserve (CVR) correlates with the perfusion state of infarct zone in early recovery phase of acute anterior myocardial infarction (AMI). We studied 14 patients (11 males; mean age, 46 years) who had AMI and 6 control subjects who had chest pain but normal coronary angiograms. All patients underwent successful percutaneous revascularization of left anterior descending (LAD) coronary artery. Coronary flow velocity was measured using intracoronary (IC) Doppler at baseline and following IC injection of 18 microg of adenosine. Myocardial perfusion was evaluated by myocardial contrast echocardiography (MCE). CVR was higher in patients without a perfusion defect on MCE than in those with (2.48 +/- 0.21 vs. 1.66 +/- 0.13, P = 0.001). Subjects with a perfusion defect had a lower CVR than controls (1.66 +/- 0.13 vs.2.40 +/- 0.18, P < 0.05). CVR was > 2.0 in all subjects without a perfusion defect. There was a strong correlation between the magnitude of myocardial opacification in the LAD territory and CVR (r = 0.80, P < 0.01). Increase in peak diastolic flow velocity after adenosine infusion, but not systolic flow velocity, correlated with myocardial opacification index (r = 0.63, P = 0.016). CVR of infarct-related artery correlated closely with the perfusion status of the myocardium in infarct zone and those with a CVR > 2.0 had normal myocardial perfusion. These data suggest that CVR may be used to determine the perfusion state of the myocardium in the infarct zone, which is a known predictor of myocardial viability. Cathet. Cardiovasc. Intervent. 51:281-286, 2000. CI - Copyright 2000 Wiley-Liss, Inc. FAU - Lim, D S AU - Lim DS AD - Department of Cardiology, Korea University Hospital, Seoul, Korea. FAU - Kim, Y H AU - Kim YH FAU - Lee, H S AU - Lee HS FAU - Park, C G AU - Park CG FAU - Seo, H S AU - Seo HS FAU - Shim, W J AU - Shim WJ FAU - Oh, D J AU - Oh DJ FAU - Ro, Y M AU - Ro YM LA - eng PT - Journal Article PL - United States TA - Catheter Cardiovasc Interv JT - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JID - 100884139 SB - IM MH - Aged MH - Blood Flow Velocity MH - Coronary Vessels/*physiopathology MH - Female MH - Hemodynamics MH - Humans MH - Male MH - Middle Aged MH - Myocardial Infarction/diagnostic imaging/*physiopathology MH - Ultrasonography, Interventional MH - *Vasodilation EDAT- 2000/11/07 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/11/07 11:00 PHST- 2000/11/07 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/11/07 11:00 [entrez] AID - 10.1002/1522-726X(200011)51:3<281::AID-CCD7>3.0.CO;2-O [pii] AID - 10.1002/1522-726x(200011)51:3<281::aid-ccd7>3.0.co;2-o [doi] PST - ppublish SO - Catheter Cardiovasc Interv. 2000 Nov;51(3):281-6. doi: 10.1002/1522-726x(200011)51:3<281::aid-ccd7>3.0.co;2-o.