PMID- 11069034
OWN - NLM
STAT- MEDLINE
DCOM- 20001122
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 14
IP  - 11
DP  - 2000 Nov
TI  - Deletions of chromosome 13q in monoclonal gammopathy of undetermined 
      significance.
PG  - 1975-9
AB  - Since deletion of chromosome 13q is a clinically relevant feature in multiple 
      myeloma (MM), we analyzed bone marrow plasma cells from 29 patients with 
      monoclonal gammopathy of undetermined significance (MGUS) to investigate the 
      chromosome 13 status in MGUS. Studies were performed by interphase fluorescence 
      in situ hybridization (FISH) with a panel of 13q14-specific probes (RB1, D13S319, 
      D13S25, D13S31). Plasma cells with a deletion of at least one of the 13q14 loci 
      were detected in 13 patients (44.8%) with MGUS. In five patients (17.2%), 
      deletions of all four 13q14-specific probes were observed, and the additional 
      deletion of a 13q telomeric region (D13S327) suggested loss of the entire 13q arm 
      or monosomy 13. Loss of 13q14 was observed to be monoallelic and to occur in 11.0 
      to 35.0% of plasma cells (cut-off levels for a deletion <10% with all probes). 
      Nine of 17 patients (52.9%) with MM progressing from a pre-existing MGUS had 
      evidence for a deletion of 13q14 as determined by FISH with the RB1 probe. These 
      results suggest that deletion of 13q14 is an early event in the development of 
      monoclonal gammopathies, but its role for the eventual progression to MM remains 
      to be determined prospectively.
FAU - Konigsberg, R
AU  - Konigsberg R
AD  - First Department of Internal Medicine, University of Vienna, Austria.
FAU - Ackermann, J
AU  - Ackermann J
FAU - Kaufmann, H
AU  - Kaufmann H
FAU - Zojer, N
AU  - Zojer N
FAU - Urbauer, E
AU  - Urbauer E
FAU - Kromer, E
AU  - Kromer E
FAU - Jager, U
AU  - Jager U
FAU - Gisslinger, H
AU  - Gisslinger H
FAU - Schreiber, S
AU  - Schreiber S
FAU - Heinz, R
AU  - Heinz R
FAU - Ludwig, H
AU  - Ludwig H
FAU - Huber, H
AU  - Huber H
FAU - Drach, J
AU  - Drach J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Paraproteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 13/genetics/*ultrastructure
MH  - Disease Progression
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Middle Aged
MH  - Monosomy
MH  - Multiple Myeloma/genetics/pathology
MH  - Paraproteinemias/*genetics/pathology
MH  - Paraproteins/analysis
MH  - Plasma Cells/ultrastructure
EDAT- 2000/11/09 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - 10.1038/sj.leu.2401909 [doi]
PST - ppublish
SO  - Leukemia. 2000 Nov;14(11):1975-9. doi: 10.1038/sj.leu.2401909.