PMID- 11069128
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20190921
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 12
IP  - 11
DP  - 2000 Nov
TI  - Steroid implants in the medial preoptic area or ventromedial nucleus of the 
      hypothalamus activate female sexual behaviour in the musk shrew.
PG  - 1124-32
AB  - Female musk shrews are induced ovulators that do not exhibit a spontaneous 
      behavioural oestrous cycle. Testosterone produced by the ovaries and adrenal 
      glands, is the major steroid hormone in circulation at times of mating, and as 
      such, regulates sexual behaviour. In the first experiment, we identified the 
      neural site(s) of action for testosterone. Hormone implants were placed in one of 
      three targeted brain regions. The neural sites selected were the medial anterior 
      division of the bed nucleus of the stria terminalis (BNSTMA), medial preoptic 
      area (mPOA) and the ventromedial nucleus of the hypothalamus (VMN). 
      Ovariectomized females who received a unilateral testosterone propionate implant 
      in either the mPOA or VMN, were significantly more likely to display sexual 
      behaviour as compared to females who received an implant in the BNSTMA or any 
      other hypothalamic nucleus. In experiments 2 and 3, we investigated whether the 
      behavioural effects of testosterone propionate were mediated by an oestrogen 
      receptor or the androgen receptor. Ovariectomized females that received 
      oestradiol (E2) implants in either the mPOA or VMN were more likely to display 
      receptivity, and had significantly shorter behavioural latencies, as compared to 
      females implanted with either dihydrotestosterone or cholesterol. These data show 
      that neural aromatization of testosterone to E2 in the mPOA or VMN is necessary 
      for optimal activation of female musk shrew sexual behaviour. This finding 
      implies a degree of neural redundancy in the networks that control the expression 
      of sexual receptivity.
FAU - Veney, S L
AU  - Veney SL
AD  - Department of Biology, University of Virginia, Charlottesville 22904-4328, USA.
FAU - Rissman, E F
AU  - Rissman EF
LA  - eng
GR  - HD072323/HD/NICHD NIH HHS/United States
GR  - K02 MH01349/MH/NIMH NIH HHS/United States
GR  - R01 NS35429/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Drug Implants)
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Estrogen)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Drug Implants
MH  - Estradiol/*administration & dosage/pharmacology
MH  - Female
MH  - Hypothalamus/drug effects
MH  - Hypothalamus, Middle/*drug effects
MH  - Ovariectomy
MH  - Preoptic Area/*drug effects
MH  - Receptors, Androgen/drug effects/physiology
MH  - Receptors, Estrogen/drug effects/physiology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Shrews/*physiology
MH  - Testosterone/*administration & dosage/pharmacology
EDAT- 2000/11/09 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - 10.1046/j.1365-2826.2000.00567.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2000 Nov;12(11):1124-32. doi: 
      10.1046/j.1365-2826.2000.00567.x.