PMID- 11069818
OWN - NLM
STAT- MEDLINE
DCOM- 20001214
LR  - 20101118
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 162
IP  - 5
DP  - 2000 Nov
TI  - Genome screen for asthma and related phenotypes in the French EGEA study.
PG  - 1812-8
AB  - A genome-wide search was conducted in 107 nuclear families with at least two 
      siblings with asthma, as part of the French EGEA study. A two-stage analysis 
      strategy was applied to the 107 families divided into two independent subsets of 
      46 and 61 families, where all regions detected in the first set of families were 
      tested for replication in the second set. In addition, all regions reported by 
      published genome scans in different populations were examined in the total 
      sample. A total of 254 markers were typed in the first set of families and 70% of 
      them in the second set. Linkage was investigated by model-free methods for asthma 
      and four asthma-related phenotypes: bronchial responsiveness (BR), skin test 
      response, total immunoglobulin E (IgE) levels, and eosinophil count. The 
      two-stage analysis led to the detection of three regions: 11p13 for IgE, 12q24 
      for eosinophils, and 17q12-21 for asthma and skin tests. Among the regions 
      reported by published genome screens, seven were found in the 107 French EGEA 
      families: three being already detected by the two-stage analysis, 11p13 (p = 
      0.005), 12q24 (p = 0.0008), and 17q12-21 (p = 0.001), and four additional ones, 
      1p31 (p = 0.005) for asthma, 11q13 (p = 0.006) for IgE, 13q31 (p = 0.001) for 
      eosinophils, and 19q13 (p = 0.02) for BR.
FAU - Dizier, M H
AU  - Dizier MH
AD  - INSERM U155, Universite Paris 7, Paris, France; INSERM EPI 00-06, H opital St 
      Louis, Paris, France. dizier@kb.inserm.fr
FAU - Besse-Schmittler, C
AU  - Besse-Schmittler C
FAU - Guilloud-Bataille, M
AU  - Guilloud-Bataille M
FAU - Annesi-Maesano, I
AU  - Annesi-Maesano I
FAU - Boussaha, M
AU  - Boussaha M
FAU - Bousquet, J
AU  - Bousquet J
FAU - Charpin, D
AU  - Charpin D
FAU - Degioanni, A
AU  - Degioanni A
FAU - Gormand, F
AU  - Gormand F
FAU - Grimfeld, A
AU  - Grimfeld A
FAU - Hochez, J
AU  - Hochez J
FAU - Hyne, G
AU  - Hyne G
FAU - Lockhart, A
AU  - Lockhart A
FAU - Luillier-Lacombe, M
AU  - Luillier-Lacombe M
FAU - Matran, R
AU  - Matran R
FAU - Meunier, F
AU  - Meunier F
FAU - Neukirch, F
AU  - Neukirch F
FAU - Pacheco, Y
AU  - Pacheco Y
FAU - Parent, V
AU  - Parent V
FAU - Paty, E
AU  - Paty E
FAU - Pin, I
AU  - Pin I
FAU - Pison, C
AU  - Pison C
FAU - Scheinmann, P
AU  - Scheinmann P
FAU - Thobie, N
AU  - Thobie N
FAU - Vervloet, D
AU  - Vervloet D
FAU - Kauffmann, F
AU  - Kauffmann F
FAU - Feingold, J
AU  - Feingold J
FAU - Lathrop, M
AU  - Lathrop M
FAU - Demenais, F
AU  - Demenais F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Genetic Markers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/*genetics/immunology/physiopathology
MH  - Bronchial Hyperreactivity
MH  - Child
MH  - Eosinophils
MH  - Female
MH  - France
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - *Genome
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Leukocyte Count
MH  - Male
MH  - Microsatellite Repeats
MH  - *Phenotype
MH  - Skin Tests
EDAT- 2000/11/09 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - 10.1164/ajrccm.162.5.2002113 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2000 Nov;162(5):1812-8. doi: 
      10.1164/ajrccm.162.5.2002113.