PMID- 11069843
OWN - NLM
STAT- MEDLINE
DCOM- 20001214
LR  - 20081121
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 162
IP  - 5
DP  - 2000 Nov
TI  - Increased levels of interleukin-18 in patients with pulmonary sarcoidosis.
PG  - 1979-82
AB  - Interleukin-18 (IL-18) has recently been identified as an interferon-gamma 
      (IFN-gamma)-inducing factor, and it plays an important role in T helper 1 (Th1) 
      response. We measured the serum levels of IL-18 and IFN- gamma in 37 patients 
      with pulmonary sarcoidosis and 25 healthy control subjects. We also measured the 
      levels of IL-18 and IFN-gamma in 10-fold concentrated bronchoalveolar lavage 
      (BAL) fluids of 19 patients with pulmonary sarcoidosis and 9 healthy control 
      subjects (all lifelong nonsmokers). The levels of serum IL-18 and IFN-gamma were 
      significantly increased in patients with sarcoidosis. The levels of BAL fluid 
      IL-18 were significantly elevated in patients with sarcoidosis, however, the 
      IFN-gamma levels of the patients and control subjects were all below sensitivity. 
      Serum IL-18 levels significantly correlated with serum IFN-gamma levels and 
      lysozyme activity. The patients positive for gallium-67 ((67)Ga) scan had 
      significantly elevated serum IL-18 levels as compared with those of the negative 
      patients. BAL fluid IL-18 levels significantly correlated with serum IL-18 levels 
      in patients with sarcoidosis, and there was a significant correlation between 
      IL-18 levels and lymphocyte proportions in sarcoid BAL fluids. In patients with 
      sarcoidosis, IL-18 seems to induce IFN-gamma production and IL-18 levels in sera 
      may reflect disease activity of sarcoidosis.
FAU - Shigehara, K
AU  - Shigehara K
AD  - Third Department of Internal Medicine and First Department of Pathology, Sapporo 
      Medical University School of Medicine, Hokkaido Branch of the Japan 
      Anti-tuberculosis Association, Sapporo, Japan.
FAU - Shijubo, N
AU  - Shijubo N
FAU - Ohmichi, M
AU  - Ohmichi M
FAU - Yamada, G
AU  - Yamada G
FAU - Takahashi, R
AU  - Takahashi R
FAU - Okamura, H
AU  - Okamura H
FAU - Kurimoto, M
AU  - Kurimoto M
FAU - Hiraga, Y
AU  - Hiraga Y
FAU - Tatsuno, T
AU  - Tatsuno T
FAU - Abe, S
AU  - Abe S
FAU - Sato, N
AU  - Sato N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Interleukin-18)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interferon-gamma/analysis/blood
MH  - Interleukin-18/*analysis/blood
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis, Pulmonary/*metabolism
EDAT- 2000/11/09 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/11/09 11:00
PHST- 2000/11/09 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/11/09 11:00 [entrez]
AID - 10.1164/ajrccm.162.5.9911113 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2000 Nov;162(5):1979-82. doi: 
      10.1164/ajrccm.162.5.9911113.